Potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 -
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of fms related receptor tyrosine kinase 1;Inhibit
Product Description
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors.
1.Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J et al.. (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.. Cancer Res, 68 (12):(4774-82). [PMID:18559524]
2.Stopfer P, Rathgen K, Bischoff D, Lüdtke S, Marzin K, Kaiser R, Wagner K, Ebner T. (2011) Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers.. Xenobiotica, 41 (4):(297-311). [PMID:21204634]
3.Dimitroulis IA. (2014) Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis.. Respir Care, 59 (9):(1450-5). [PMID:24782550]
4.Hunninghake GM. (2014) A new hope for idiopathic pulmonary fibrosis.. N Engl J Med, 370 (22):(2142-3). [PMID:24836311]
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G2418484