Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab170544-100μg | 100μg | In stock | $59.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Nipocalimab (anti-FcRn) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to FCGRT, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | Anti-FcRn (FCGRT & B2M) Reference Antibody (nipocalimab); M281; Nipocalimab; Alpha chain antibody; Fc fragment of IgG, receptor transporter, alpha antibody; FCGRN_HUMAN antibody; FCGRT antibody; FcRn alpha chain antibody; FcRn antibody; FCRN, alpha chain |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | FCGRT |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | ANTAGONIST of IgG receptor FcRn large subunit p51 antagonist |
| Product Description | Nipocalimab (anti-FcRn) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG1 |
| Light Chain Type | lambda C2 |
| SDS-PAGE | 27.4 kDa (Light Chain) & 49.4 kDa (Heavy Chain), under reducing conditions; 170.8 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2211985-36-1 |
Nipocalimab (anti-FcRn) (Ab170544) - ELISA
Immobilized Human FcRn/FCGRT&B2M Heterodimer protein, His and Avi tag at 2.0 μg/mL can bind Nipocalimab (anti-FcRn) (Ab170544) with the EC₅₀ of 4.95 ng/mL.
Nipocalimab (anti-FcRn) (Ab170544) - SEC
The purity of Nipocalimab (anti-FcRn) (Ab170544) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0303675 | Certificate of Analysis | Mar 25, 2024 | Ab170544 |
| ZJ24F0303674 | Certificate of Analysis | Mar 25, 2024 | Ab170544 |
| ZJ24F0303673 | Certificate of Analysis | Mar 25, 2024 | Ab170544 |
| 1. Nixon AE, Chen J, Sexton DJ, Muruganandam A, Bitonti AJ, Dumont J, Viswanathan M, Martik D, Wassaf D, Mezo A et al.. (2015) Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.. Front Immunol, 6 (3): (176). [PMID:25954273] |
| 2. McDonnell KA, Low SC, Hoehn T, Donnelly R, Palmieri H, Fraley C, Sakorafas P, Mezo AR.. (2010) Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction.. J Med Chem, 53 (4): (1587-1596). [PMID:20092334] |
| 3. Story, C M CM, Mikulska, J E JE and Simister, N E NE.. (1994) A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.. The Journal of experimental medicine, (1): [PMID:7964511] |
| 4. West, A P AP and Bjorkman, P J PJ.. (2000) Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,).. Biochemistry, (15): [PMID:10933786] |
| 5. Mikulska, J E JE, Pablo, L L, Canel, J J and Simister, N E NE.. (2000) Cloning and analysis of the gene encoding the human neonatal Fc receptor.. European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, [PMID:10998088] |
| 6. Oganesyan, Vaheh V and 6 more authors.. (2014) Structural insights into neonatal Fc receptor-based recycling mechanisms.. The Journal of biological chemistry, (14): [PMID:24469444] |
| 7. Morosky, Stefanie S and 6 more authors.. (2019) The neonatal Fc receptor is a pan-echovirus receptor.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:30808762] |
| 8. Zhao, Xin X and 27 more authors.. (2019) Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.. Cell, (30): [PMID:31104841] |
