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nor-Binaltorphimine (nor-BNI) - ≥98%, high purity , CAS No.105618-26-6, Antagonist of δ receptor;Antagonist of κ receptor;Antagonist of μ receptor

Moligand™
≥98%

CAS#: 105618-26-6
Formula: C₄₀H₄₃N₃O₆.2HCl
Molecular Weight: 734.72
PubChem CID: 5480230

Item Number

N275281

Grouped product items
SKU	Size	Availability	Price	Qty
N275281-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$407.90

Potent and selective κ opioid receptor antagonist

View related series

δ receptor Antagonist κ receptor Antagonist μ receptor Antagonist

Basic Description

Synonyms	Norbinaltorphimine\|nor-Binaltorphimine\|105618-26-6\|Nor-bni\|NorBNI\|36OOQ86QM1\|CHEBI:81529\|C18130\|(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,3
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent and selective κ opioid receptor antagonist
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of δ receptor;Antagonist of κ receptor;Antagonist of μ receptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

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MAPK8 Tchem Mitogen-activated protein kinase 8 0 Activities

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ATXN2 Tbio Ataxin-2 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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OPRD1 Tclin Delta-type opioid receptor 28 Activities

Discover Target: OPRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 33 Activities

Discover Target: OPRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 16 Activities

Discover Target: OPRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol
INCHI	InChI=1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+,39-,40-/m1/s1
InChi Key	APSUXPSYBJVPPS-YAUKWVCOSA-N
Canonical SMILES	C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1
Isomeric SMILES	C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1
Alternate CAS	113158-34-2
PubChem CID	5480230
Molecular Weight	734.72

PubChem CID

Wikipedia

BindingDB Ligand

CAS Registry No.

ChEMBL Ligand

GPCRdb Ligand

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2 results found

Lot Number	Certificate Type	Date	Item
J2330497	Certificate of Analysis	Aug 19, 2024	N275281
C2308809	Certificate of Analysis	Dec 19, 2023	N275281

Solubility

Soluble in water to 50 mM

Sensitivity

Light sensitive；Moisture sensitive

References

1. Huang H et al.. (2022) Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.. Pain Res Manag, 2022 (4819910). [PMID:35646201]
2. Makino Y et al.. (2022) Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.. Commun Biol, 5 (299). [PMID:35365763]
3. Li TF et al.. (2016) Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing.. Front Pharmacol, 7 (367). [PMID:27761113]
4. Barbaro JM et al.. (2022) Morphine disrupts macrophage functions even during HIV infection.. J Leukoc Biol, 112 (5): (1317-1328). [PMID:36205434]
5. Sun J et al.. (2019) Salvinorin A attenuates early brain injury through PI3K/Akt pathway after subarachnoid hemorrhage in rat.. Brain Res, 1719 (64-70). [PMID:31125530]
6. Azocar VH et al.. (2019) The blocking of kappa-opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization.. J Neurochem, 148 (3): (348-358). [PMID:30315655]
7. He Y et al.. (2019) Transgenic increase in the ß-endorphin concentration in cerebrospinal fluid alleviates morphine-primed relapse behavior through the µ opioid receptor in rats.. J Med Virol, 91 (6): (1158-1167). [PMID:30701563]

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