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norendoxifen , CAS No.N612359, Inhibitor of CYP19A1;Antagonist of Estrogen receptor-α;Agonist of Estrogen receptor-β

Moligand™

PubChem CID: 68037237

Item Number

N612359

Grouped product items
SKU	Size	Availability	Price	Qty
N612359-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$390.90
N612359-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90

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CYP19A1 Inhibitor Estrogen receptor-α Antagonist Estrogen receptor-β Agonist

Basic Description

Synonyms	Norendoxifen\|Z-Norendoxifen\|51GJD354B5\|UNII-51GJD354B5\|CHEMBL2386284\|1308808-22-1\|(E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen\|4-((1Z)-1-(4-(2-Aminoethoxy)phenyl)-2-phenyl-1-buten-1-yl)phenol\|Phenol, 4-((1Z)-1-(4-(2-aminoethoxy)phenyl)-2-phenyl-1-buten-1-yl)
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST, INHIBITOR
Mechanism of action	Inhibitor of CYP19A1;Antagonist of Estrogen receptor-α;Agonist of Estrogen receptor-β

Associated Targets

ESR1 Tclin Estrogen receptor 3 Activities

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR2 Tclin Estrogen receptor beta 3 Activities

Discover Target: ESR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP19A1 Tclin Aromatase 3 Activities

Discover Target: CYP19A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[(~{Z})-1-[4-(2-aminoethoxy)phenyl]-2-phenylbut-1-enyl]phenol
INCHI	InChI=1S/C24H25NO2/c1-2-23(18-6-4-3-5-7-18)24(19-8-12-21(26)13-9-19)20-10-14-22(15-11-20)27-17-16-25/h3-15,26H,2,16-17,25H2,1H3/b24-23-
InChi Key	YCQBLTPGQSYLHD-VHXPQNKSSA-N
Canonical SMILES	NCCOc1ccc(cc1)/C(=C(\c1ccccc1)/CC)/c1ccc(cc1)O
Isomeric SMILES	CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN)/C3=CC=CC=C3
PubChem CID	68037237

PubChem CID

68037237

BindingDB Ligand

50435004

ChEMBL Ligand

CHEMBL2386284

References

1. Lu WJ, Xu C, Pei Z, Mayhoub AS, Cushman M, Flockhart DA. (2012) The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.. Breast Cancer Res Treat, 133 (1): (99-109). [PMID:21814747]
2. Lv W, Liu J, Lu D, Flockhart DA, Cushman M. (2013) Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.. J Med Chem, 56 (11): (4611-8). [PMID:23731360]

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norendoxifen , CAS No.N612359, Inhibitor of CYP19A1;Antagonist of Estrogen receptor-α;Agonist of Estrogen receptor-β

Basic Description

Associated Targets

ESR1 Tclin Estrogen receptor 3 Activities

ESR2 Tclin Estrogen receptor beta 3 Activities

CYP19A1 Tclin Aromatase 3 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator