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NS 11021 - ≥98%(HPLC), high purity , CAS No.956014-19-0, Activator of K Ca1.1

Moligand™
≥98%(HPLC)

CAS#: 956014-19-0
Formula: C₁₆H₉BrF₆N₆S
Molecular Weight: 511.24
PubChem CID: 24825677

Item Number

N287933

Grouped product items
SKU	Size	Availability	Price	Qty
N287933-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$395.90
N287933-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,782.90

KCa1.1 (BK) channel activator

View related series

KCa1.1 Activator

Basic Description

Synonyms	956014-19-0\|NS 11021\|ns11021\|1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea\|NS-11021\|1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea\|1-(3,5-Bis-trifluoromethyl-phenyl)-3-[4-bromo-2-(1H-t
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+(KV), Na+and Ca2+currents at concentrations <10μM. Alters gating kinetics, but does not affect single channel conductance. Sho
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of K Ca1.1

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 0 Activities

Discover Target: KCNMA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea
INCHI	InChI=1S/C16H9BrF6N6S/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
InChi Key	MDKAFDIKYQMOMF-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1Br)C2=NNN=N2)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
Isomeric SMILES	C1=CC(=C(C=C1Br)C2=NNN=N2)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
PubChem CID	24825677
Molecular Weight	511.24

PubChem CID

24825677

CAS Registry No.

956014-19-0

ChEMBL Ligand

CHEMBL4303589

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H413:May cause long lasting harmful effects to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.

References

1. Kun A, Matchkov VV, Stankevicius E, Nardi A, Hughes AD, Kirkeby HJ, Demnitz J, Simonsen U. (2009) NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats.. Br J Pharmacol, 158 (6): (1465-76). [PMID:19845682]
2. Layne JJ, Nausch B, Olesen SP, Nelson MT. (2010) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.. Am J Physiol Regul Integr Comp Physiol, 298 (2): (R378-84). [PMID:19923353]
3. Bentzen BH, Nardi A, Calloe K, Madsen LS, Olesen SP, Grunnet M. (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.. Mol Pharmacol, 72 (4): (1033-44). [PMID:17636045]

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NS 11021 - ≥98%(HPLC), high purity , CAS No.956014-19-0, Activator of K Ca1.1

Basic Description

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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