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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B135630-10mg | 10mg | In stock | $70.90 | |
B135630-50mg | 50mg | In stock | $238.90 |
HERG (Kv11.1) channel activator
Synonyms | 448895-37-2|NS1643|1,3-Bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea|NS-1643|NS 1643|1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea|C15H10F6N2O3|N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea|0I579CNG0I|1,3-Bis(2-hydroxy-5-trifluoromethylphenyl)urea|U |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | HERG (Kv11.1) channel activator (EC 50 = 10.5 μM). Increases erg2 (Kv11.2) currents. Displays antiarrhythmic activity in vitro . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of K Ca1.1;Activator of K v11.1;Activator of K v11.2;Activator of K v11.3 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | 1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea |
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INCHI | InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26) |
InChi Key | NJFVQMRYJZHGME-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O |
Isomeric SMILES | C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O |
WGK Germany | 3 |
PubChem CID | 10177784 |
Molecular Weight | 380.24 |
PubChem CID | 10177784 |
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CAS Registry No. | 448895-37-2 |
ChEMBL Ligand | CHEMBL1514181 |
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Solubility | Soluble in ethanol to 100 mM and in DMSO to 25 mM |
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Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H301:Toxic if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 3 |