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NS-1643 - ≥98% (HPLC), high purity , CAS No.448895-37-2, Activator of K Ca1.1;Activator of K v11.1;Activator of K v11.2;Activator of K v11.3

  • Moligand™
  • ≥98%(HPLC)
Item Number
B135630
Grouped product items
SKUSizeAvailabilityPrice Qty
B135630-10mg
10mg
In stock
$70.90
B135630-50mg
50mg
In stock
$238.90

HERG (Kv11.1) channel activator

Basic Description

Synonyms448895-37-2|NS1643|1,3-Bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea|NS-1643|NS 1643|1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea|C15H10F6N2O3|N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea|0I579CNG0I|1,3-Bis(2-hydroxy-5-trifluoromethylphenyl)urea|U
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsHERG (Kv11.1) channel activator (EC 50 = 10.5 μM). Increases erg2 (Kv11.2) currents. Displays antiarrhythmic activity in vitro .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of K Ca1.1;Activator of K v11.1;Activator of K v11.2;Activator of K v11.3
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH7 Tclin Potassium voltage-gated channel subfamily H member 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH6 Tclin Potassium voltage-gated channel subfamily H member 6 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1,3-bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
INCHI InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
InChi Key NJFVQMRYJZHGME-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O
Isomeric SMILES C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O
WGK Germany 3
PubChem CID 10177784
Molecular Weight 380.24

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
D2107047Certificate of AnalysisJan 15, 2023 B135630
D2107050Certificate of AnalysisJan 15, 2023 B135630

Chemical and Physical Properties

SolubilitySoluble in ethanol to 100 mM and in DMSO to 25 mM

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H319:Causes serious eye irritation

H301:Toxic if swallowed

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

WGK Germany 3

Related Documents

Solution Calculators