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NS 3623 - 98%, high purity , CAS No.343630-41-1, Activator of K v11.1
KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
Basic Description Synonyms 343630-41-1|ns3623|NS 3623|NS-3623|1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea|J9HB2T5SS4|1-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea|N-(4-bromo-2-(1h-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylp Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms KV11.1 (hERG) and KV4.3 channel activator. Activate IKrandItocurrents and display anti-arrhythmic activities. It can also act as a partial blocker of the KV11.1 channel. Shows the selectivity to key cardiac potassium channels KV7.1 (KCNQ1) and KV1.5.
Storage Temp Protected from light,Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ACTIVATOR Mechanism of action Activator of K v11.1
Names and Identifiers IUPAC Name 1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea INCHI InChI=1S/C15H10BrF3N6O/c16-9-4-5-12(11(7-9)13-22-24-25-23-13)21-14(26)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H2,20,21,26)(H,22,23,24,25) InChi Key JXPULDIATMTIIN-UHFFFAOYSA-N Canonical SMILES C1=CC(=CC(=C1)NC(=O)NC2=C(C=C(C=C2)Br)C3=NNN=N3)C(F)(F)F Isomeric SMILES C1=CC(=CC(=C1)NC(=O)NC2=C(C=C(C=C2)Br)C3=NNN=N3)C(F)(F)F PubChem CID 9954236 Molecular Weight 427.18
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 42.72, Max Conc. mM: 100 Sensitivity light sensitive
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H2316173