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Targets
Ligand-gated ion channels
Acid-sensing (proton-gated) ion channels (ASICs)
NS 383 , CAS No.309711-59-9, Channel blocker of ASIC1;Channel blocker of ASIC3

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NS 383 , CAS No.309711-59-9, Channel blocker of ASIC1;Channel blocker of ASIC3

Moligand™

CAS#: 309711-59-9
Formula: C₁₉H₁₉N₃O₂
Molecular Weight: 321.37
PubChem CID: 135418391

Item Number

N288698

Grouped product items
SKU	Size	Availability	Price	Qty
N288698-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$137.90
N288698-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$563.90

ASIC blocker; activein vivo

View related series

ASIC1 Channel blocker ASIC3 Channel blocker

Basic Description

Synonyms	8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of ASIC1;Channel blocker of ASIC3

Associated Targets

ASIC3 Tchem Acid-sensing ion channel 3 0 Activities

Discover Target: ASIC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ASIC1 Tchem Acid-sensing ion channel 1 0 Activities

Discover Target: ASIC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	8-ethyl-3-nitroso-5-phenyl-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-2-ol
INCHI	InChI=1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,20,23H,2,8-9,11H2,1H3
InChi Key	OZVZKENYKWSYBC-UHFFFAOYSA-N
Canonical SMILES	CCN1CCC2=C(C=C3C(=C2C1)NC(=C3N=O)O)C4=CC=CC=C4
PubChem CID	135418391
Molecular Weight	321.37

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 1.61, Max Conc. mM: 5

References

1. Munro G, Christensen JK, Erichsen HK, Dyhring T, Demnitz J, Dam E, Ahring PK. (2016) NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats.. CNS Neurosci Ther, 22 (2): (135-45). [PMID:26663905]

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