Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N287207-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $117.90 | |
N287207-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $187.90 | |
N287207-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $423.90 | |
N287207-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $761.90 | |
N287207-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,370.90 |
KV4.3 channel activator
Synonyms | 426834-69-7|NS 5806|NS5806|NS-5806|1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea|N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea|1-(3,5-bis(trifluoromethyl)phenyl)-3-(2,4-dibromo-6-(2H |
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Specifications & Purity | ≥99%(HPLC) |
Biochemical and Physiological Mechanisms | KV4.3 channel activator; mediates the transient outward K+current (Ito). Increases IKv4.3peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50= 5.3μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea |
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INCHI | InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30) |
InChi Key | UZWJWROOLOOCPQ-UHFFFAOYSA-N |
Canonical SMILES | C1=C(C=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=C(C=C2Br)Br)C3=NNN=N3)C(F)(F)F |
Isomeric SMILES | C1=C(C=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=C(C=C2Br)Br)C3=NNN=N3)C(F)(F)F |
PubChem CID | 11642685 |
Molecular Weight | 574.07 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 57.41, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 28.7, Max Conc. mM: 50 |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H413:May cause long lasting harmful effects to aquatic life |
Precautionary Statements | P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |