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NS 5806 - ≥99%(HPLC), high purity , CAS No.426834-69-7

  • ≥99%(HPLC)
Item Number
N287207
Grouped product items
SKUSizeAvailabilityPrice Qty
N287207-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$117.90
N287207-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$187.90
N287207-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$423.90
N287207-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$761.90
N287207-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,370.90

KV4.3 channel activator

Basic Description

Synonyms426834-69-7|NS 5806|NS5806|NS-5806|1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea|N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea|1-(3,5-bis(trifluoromethyl)phenyl)-3-(2,4-dibromo-6-(2H
Specifications & Purity≥99%(HPLC)
Biochemical and Physiological MechanismsKV4.3 channel activator; mediates the transient outward K+current (Ito). Increases IKv4.3peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50= 5.3μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

 

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
INCHI InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)
InChi Key UZWJWROOLOOCPQ-UHFFFAOYSA-N
Canonical SMILES C1=C(C=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=C(C=C2Br)Br)C3=NNN=N3)C(F)(F)F
Isomeric SMILES C1=C(C=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=C(C=C2Br)Br)C3=NNN=N3)C(F)(F)F
PubChem CID 11642685
Molecular Weight 574.07

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 57.41, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 28.7, Max Conc. mM: 50

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H413:May cause long lasting harmful effects to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

Related Documents

Solution Calculators