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NTE-1 , CAS No.N612429, Inhibitor of insulin degrading enzyme

Item Number

N612429

Grouped product items
SKU	Size	Availability	Price	Qty
N612429-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
N612429-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of insulin degrading enzyme

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	methyl N-[(2S)-2-[4-[5-[4-[[(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino]phenyl]pentoxy]phenyl]-3-quinolin-3-ylpropyl]carbamate
INCHI	InChI=1S/C44H55N5O5/c1-53-44(52)47-30-36(28-32-27-35-14-7-8-16-40(35)46-29-32)33-19-23-38(24-20-33)54-26-9-3-4-11-31-17-21-37(22-18-31)48-42(50)41(34-12-5-2-6-13-34)49-25-10-15-39(45)43(49)51/h7-8,14,16-24,27,29,34,36,39,41H,2-6,9-13,15,25-26,28,30,45H2,1H3,(H,47,52)(H,48,50)/t36-,39+,41+/m1/s1
InChi Key	IGRIVAWLJUPVMM-UDEWTJCRSA-N
Canonical SMILES	COC(=O)NC[C@H](c1ccc(cc1)OCCCCCc1ccc(cc1)NC(=O)[C@@H](N1CCC[C@@H](C1=O)N)C1CCCCC1)Cc1cnc2c(c1)cccc2
Isomeric SMILES	COC(=O)NC[C@@H](CC1=CC2=CC=CC=C2N=C1)C3=CC=C(C=C3)OCCCCCC4=CC=C(C=C4)NC(=O)[C@H](C5CCCCC5)N6CCC[C@@H](C6=O)N
PubChem CID	91801116

PubChem CID	91801116
RCSB PDB Ligand	2Q6

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1. Durham TB, Toth JL, Klimkowski VJ, Cao JX, Siesky AM, Alexander-Chacko J, Wu GY, Dixon JT, McGee JE, Wang Y et al.. (2015) Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.. J Biol Chem, 290 (33): (20044-59). [PMID:26085101]

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