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NTE-2 , CAS No.N612430, Inhibitor of insulin degrading enzyme

Item Number

N612430

Grouped product items
SKU	Size	Availability	Price	Qty
N612430-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
N612430-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of insulin degrading enzyme

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	methyl N-[(2S)-2-[5-[5-[4-[[(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl]amino]phenyl]pentyl]-2-fluorophenyl]-3-quinolin-3-ylpropyl]carbamate
INCHI	InChI=1S/C44H54FN5O4/c1-54-44(53)48-29-35(26-32-25-34-15-8-9-17-40(34)47-28-32)37-27-31(20-23-38(37)45)12-5-2-4-11-30-18-21-36(22-19-30)49-42(51)41(33-13-6-3-7-14-33)50-24-10-16-39(46)43(50)52/h8-9,15,17-23,25,27-28,33,35,39,41H,2-7,10-14,16,24,26,29,46H2,1H3,(H,48,53)(H,49,51)/t35-,39+,41+/m1/s1
InChi Key	SDVPSGCYRLUZSS-WXSHXSFMSA-N
Canonical SMILES	COC(=O)NC[C@H](c1cc(CCCCCc2ccc(cc2)NC(=O)[C@@H](N2CCC[C@@H](C2=O)N)C2CCCCC2)ccc1F)Cc1cnc2c(c1)cccc2
Isomeric SMILES	COC(=O)NC[C@@H](CC1=CC2=CC=CC=C2N=C1)C3=C(C=CC(=C3)CCCCCC4=CC=C(C=C4)NC(=O)[C@H](C5CCCCC5)N6CCC[C@@H](C6=O)N)F
PubChem CID	91801117

PubChem CID	91801117
RCSB PDB Ligand	2QX

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1. Durham TB, Toth JL, Klimkowski VJ, Cao JX, Siesky AM, Alexander-Chacko J, Wu GY, Dixon JT, McGee JE, Wang Y et al.. (2015) Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.. J Biol Chem, 290 (33): (20044-59). [PMID:26085101]

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