NTX-1088 (anti-PVR) is a first-in-class potent monoclonal antibody targeting poliovirus receptor. It can be used in treatment of patients with locally advanced and metastatic solid tumors. Purity ≥95% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg Protein Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Product Properties
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
145.86 kDa
Purification Method
Protein A purified
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
NTX-1088 (anti-PVR) (Ab190147) - Flow Cytometry Flow Cytometry analysis of A549 cells labelling CD30 (red) with NTX-1088 (anti-PVR) (Ab190147). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
NTX-1088 (anti-PVR) (Ab190147) - Flow Cytometry Flow Cytometry analysis of U937 cells labelling CD30 (red) with NTX-1088 (anti-PVR) (Ab190147). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
NTX-1088 (anti-PVR) (Ab190147) - SEC The purity of NTX-1088 (anti-PVR) (Ab190147) is more than 95% verified by HPLC.