| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| N661606-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $275.90 |
| Specifications & Purity | 10mM |
|---|---|
| Storage Temp | Argon charged,Desiccated,Store at -80°C |
| Shipped In | Dry ice |
| Product Description | Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent. IC50& Target:IC50: 86 nM (Arginase 1), 296 nM (Arginase 2) In Vitro:Numidargistat dihydrochloride is a potent and orally-bioavailable inhibitor of arginase, with IC 50 s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively. Numidargistat dihydrochloride inhibits native rginase 1 (Arg1) in human granulocyt In Vivo:Numidargistat dihydrochloride (100mg/kg, p.o., twice per day) increases the number of tumor-infiltrating cytotoxic cells and decreases myeloid cells in mice. Numidargistat dihydrochloride in combination with PD-L1 blockade or LY 188011 inhibits tumor gro Biological Activity:Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent. |
| Canonical SMILES | O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1.Cl.Cl |
|---|---|
| Molecular Weight | 360.04 |
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