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E3 ubiquitin ligase components
NVP-DKY709 , CAS No.2291360-73-9, cereblon

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NVP-DKY709 , CAS No.2291360-73-9, cereblon

Moligand™

CAS#: 2291360-73-9
PubChem CID: 137519326

Item Number

N612441

Grouped product items
SKU	Size	Availability	Price	Qty
N612441-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N612441-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

cereblon

Basic Description

Synonyms	compound 5;DKY-709;DKY709
Specifications & Purity	Moligand™
Grade	Moligand™
Mechanism of action	cereblon

Associated Targets

GSPT1 Tbio Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 Activities

Discover Target: GSPT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CRBN Tclin Protein cereblon 0 Activities

Discover Target: CRBN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IKZF1 Tbio DNA-binding protein Ikaros 0 Activities

Discover Target: IKZF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[6-(1-benzylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
INCHI	InChI=1S/C25H27N3O3/c29-23-9-8-22(24(30)26-23)28-16-20-14-19(6-7-21(20)25(28)31)18-10-12-27(13-11-18)15-17-4-2-1-3-5-17/h1-7,14,18,22H,8-13,15-16H2,(H,26,29,30)
InChi Key	OMISHRJQMYQPMG-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)C4CCN(CC4)CC5=CC=CC=C5
Isomeric SMILES	C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)C4CCN(CC4)CC5=CC=CC=C5
PubChem CID	137519326

Database links

PubChem CID	137519326
CAS Registry No.	2291360-73-9
ChEMBL Ligand	CHEMBL5077506
RCSB PDB Ligand	LWK

Certificates

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References

1. Bonazzi S, d'Hennezel E, Beckwith REJ, Xu L, Fazal A, Magracheva A, Ramesh R, Cernijenko A, Antonakos B, Bhang HC et al.. (2023) Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.. Cell Chem Biol, 30 (3): (235-247.e12). [PMID:36863346]

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