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O-Methyl-L-tyrosine - 98%, high purity , CAS No.6230-11-1

≥98%

CAS#: 6230-11-1
Formula: CH₃OC₆H₄CH₂CH(NH₂)CO₂H
Molecular Weight: 195.22
Beilstein Registry Number: 2212726
EC Number: 228-333-9
MDL number: MFCD00002604
PubChem CID: 2723935

Item Number

M117085

Grouped product items
SKU	Size	Availability	Price
M117085-200mg	200mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9.90
M117085-1g	1g	In stock	$19.90
M117085-5g	5g	In stock	$89.90
M117085-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$403.90

View related series

Peptide chemistry Side chain protected amino acids

Basic Description

Synonyms	O-Methyl-L-tyrosine\|4-Methoxy-l-phenylalanine\|6230-11-1\|H-Tyr(Me)-OH\|(2S)-2-amino-3-(4-methoxyphenyl)propanoic acid\|(S)-2-amino-3-(4-methoxyphenyl)propanoic acid\|L-Tyrosine, O-methyl-\|p-Methoxy-L-phenylalanine\|SCX8EOU7CO\|(s)-2-amino-3-(4-methoxyphenyl)pro
Specifications & Purity	98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-(4-methoxyphenyl)propanoic acid
INCHI	InChI=1S/C10H13NO3/c1-14-8-4-2-7(3-5-8)6-9(11)10(12)13/h2-5,9H,6,11H2,1H3,(H,12,13)/t9-/m0/s1
InChi Key	GEYBMYRBIABFTA-VIFPVBQESA-N
Canonical SMILES	COC1=CC=C(C=C1)CC(C(=O)O)N
Isomeric SMILES	COC1=CC=C(C=C1)C[C@@H](C(=O)O)N
WGK Germany	3
PubChem CID	2723935
Molecular Weight	195.22
Beilstein	2212726

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
E1924105	Certificate of Analysis	Mar 09, 2023	M117085
J1411058	Certificate of Analysis	Jul 15, 2022	M117085
G2216405	Certificate of Analysis	Jun 11, 2022	M117085
G2216406	Certificate of Analysis	Jun 11, 2022	M117085
G2216407	Certificate of Analysis	Jun 11, 2022	M117085

Solubility

Very soluble in water.

Sensitivity

Heat sensitive

Specific Rotation[α]

-9° (C=2,1mol/L Hcl)

Melt Point(°C)

259-261°C

References

1. Parigiani MA et al.. (2020) Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.. Cancers (Basel), 12 (8): [PMID:32707827]
2. C Lee,A Lawen. (1993-12-01) In vitro biosynthesis of peptolide SDZ 90-215 by a 1.2 MDa multienzyme polypeptide.. Biochemistry and molecular biology international, 31 ((5)): (797-805). [PMID:8136697]
3. L Wang,A Brock,B Herberich,P G Schultz. (2001-04-21) Expanding the genetic code of Escherichia coli.. Science (New York, N.Y.), 292 ((5516)): (498-500). [PMID:11313494]
4. Deqiang Zhang,Nagarajan Vaidehi,William A Goddard,Joseph F Danzer,Derek Debe. (2002-05-16) Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-L-tyrosine.. Proceedings of the National Academy of Sciences of the United States of America, 99 ((10)): (6579-6584). [PMID:12011422]
5. Robert F Service. (2003-02-01) Metabolic engineering. Researchers create first autonomous synthetic life form.. Science (New York, N.Y.), 299 ((5607)): (640-640). [PMID:12560520]
6. Lei Wang. (2003-10-25) Amersham Prize winner. Expanding the genetic code.. Science (New York, N.Y.), 302 ((5645)): (584-585). [PMID:14576413]
7. T Ashton Cropp,J Christopher Anderson,Jason W Chin. (2007-10-20) Reprogramming the amino-acid substrate specificity of orthogonal aminoacyl-tRNA synthetases to expand the genetic code of eukaryotic cells.. Nature protocols, 2 ((10)): (2590-2600). [PMID:17948002]
8. Jed N Lampe,Stephen N Floor,John D Gross,Clinton R Nishida,Yongying Jiang,Michael J Trnka,Paul R Ortiz de Montellano. (2008-11-13) Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.. Journal of the American Chemical Society, 130 ((48)): (16168-16169). [PMID:18998650]
9. Jed N Lampe,Relly Brandman,Santhosh Sivaramakrishnan,Paul R Ortiz de Montellano. (2010-01-26) Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates.. The Journal of biological chemistry, 285 ((13)): (9594-9603). [PMID:20097757]
10. Jeffrey K Takimoto,Nikki Dellas,Joseph P Noel,Lei Wang. (2011-05-07) Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids.. ACS chemical biology, 6 ((7)): (733-743). [PMID:21545173]
11. Ma Diarey Tianero,Jared N Balaich,Mohamed S Donia. (2019-04-03) Localized production of defence chemicals by intracellular symbionts of Haliclona sponges.. Nature microbiology, 4 ((7)): (1149-1159). [PMID:30936484]
12. Daniele Cervettini,Shan Tang,Stephen D Fried,Julian C W Willis,Louise F H Funke,Lucy J Colwell,Jason W Chin. (2020-04-15) Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase-tRNA pairs.. Nature biotechnology, 38 ((8)): (989-999). [PMID:32284585]
13. S E Shoelson,M F White,C R Kahn. (1989-05-15) Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases.. The Journal of biological chemistry, 264 ((14)): (7831-7836). [PMID:2498306]
14. A Böck. (2001-05-02) Molecular biology. Invading the genetic code.. Science (New York, N.Y.), 292 ((5516)): (453-454). [PMID:11330299]
15. M Manning,S Stoev,L L Cheng,N C Wo,W Y Chan. (2001-10-06) Design of oxytocin antagonists, which are more selective than atosiban.. Journal of peptide science : an official publication of the European Peptide Society, 7 ((9)): (449-465). [PMID:11587184]
16. Jason W Chin,T Ashton Cropp,J Christopher Anderson,Mridul Mukherji,Zhiwen Zhang,Peter G Schultz. (2003-08-16) An expanded eukaryotic genetic code.. Science (New York, N.Y.), 301 ((5635)): (964-967). [PMID:12920298]
17. Ning Wu,Alexander Deiters,T Ashton Cropp,David King,Peter G Schultz. (2004-11-04) A genetically encoded photocaged amino acid.. Journal of the American Chemical Society, 126 ((44)): (14306-14307). [PMID:15521721]
18. Sebastian M Kuhn,Marina Rubini,Markus Fuhrmann,Ina Theobald,Arne Skerra. (2010-09-15) Engineering of an orthogonal aminoacyl-tRNA synthetase for efficient incorporation of the non-natural amino acid O-methyl-L-tyrosine using fluorescence-based bacterial cell sorting.. Journal of molecular biology, 404 ((1)): (70-87). [PMID:20837025]
19. Debbie Dewaele,Frank Sobott,Filip Lemière. (2016-02-13) Covalent adducts of melphalan with free amino acids and a model peptide studied by liquid chromatography/tandem mass spectrometry.. Rapid communications in mass spectrometry : RCM, 30 ((6)): (719-730). [PMID:26864525]
20. Raluca Bianca Tomoiagă,Souad Diana Tork,Ilka Horváth,Alina Filip,Levente Csaba Nagy,László Csaba Bencze. (2020-06-04) Saturation Mutagenesis for Phenylalanine Ammonia Lyases of Enhanced Catalytic Properties.. Biomolecules, 10 ((6)): [PMID:32486192]
21. Stephanie Ketterer,Julia Mitschke,Anett Ketscher,Manuel Schlimpert,Wilfried Reichardt,Natascha Baeuerle,Maria Elena Hess,Patrick Metzger,Melanie Boerries,Christoph Peters,Bernd Kammerer,Tilman Brummer,Florian Steinberg,Thomas Reinheckel. (2020-10-14) Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.. Nature communications, 11 ((1)): (5133-5133). [PMID:33046706]

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O-Methyl-L-tyrosine - 98%, high purity , CAS No.6230-11-1

Basic Description

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator