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Olmesartan - ≥98%, high purity , Type-1 angiotensin II receptor antagonist, CAS No.144689-24-7, Type-1 angiotensin II receptor antagonist
Basic Description Synonyms Olmesartan|144689-24-7|Olmesartan Acid|RNH-6270|omesartan|RNH 6270|1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid|UNII-8W1IQP3U10|CS-088|NSC-759810|8W1IQP3U10|CHEBI:48416|HSDB 8214|C Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent angiotensin II type I (AT1) receptor antagonist (IC50= 6.7 nM at hAT1receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type ANTAGONIST Mechanism of action Type-1 angiotensin II receptor antagonist Product Description Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction.
Names and Identifiers Pubchem Sid 488188282 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488188282 IUPAC Name 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid INCHI InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29) InChi Key VTRAEEWXHOVJFV-UHFFFAOYSA-N Canonical SMILES CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C)(C)O Isomeric SMILES CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C)(C)O RTECS NI4014100 PubChem CID 158781 Molecular Weight 446.5
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 8.93, Max Conc. mM: 20 Sensitivity Heat Sensitive Melt Point(°C) 177 °C(dec.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H312: Harmful in contact with skin
H332: Harmful if inhaled
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
P317: Get emergency medical help.
RTECS NI4014100
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