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Olopatadine Hydrochloride - >98.0%(HPLC), high purity , Histamine H1 receptor antagonist, CAS No.140462-76-6, Histamine H1 receptor antagonist

≥98%(HPLC)

CAS#: 140462-76-6
Formula: C₂₁H₂₃NO₃·HCl
Molecular Weight: 373.88
MDL number: MFCD00875716
PubChem CID: 5282402
PubChem SID: 488195259

Item Number

O159894

Grouped product items
SKU	Size	Availability	Price
O159894-250mg	250mg	In stock	$72.90
O159894-1g	1g	In stock	$222.90
O159894-5g	5g	In stock	$1,000.90
O159894-25g	25g	In stock	$4,501.90

Selective H 1 receptor antagonist

View related series

Histamine receptor antagonists Seven membered ring compound

Basic Description

Synonyms	OLOPATADINE HYDROCHLORIDE\|140462-76-6\|OLOPATADINE HCl\|Allelock\|Pataday\|Patanase\|Pazeo\|ALO4943A\|Olopine\|Patadine\|Olopax\|KW4679\|ALO-4943A\|Olopatadine (hydrochloride)\|UNII-2XG66W44KF\|KW-4679\|Olopatadine (as hydrochloride)\|2XG66W44KF\|(Z)-2-(11-(3-(dimethylami
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limi
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	ANTAGONIST
Mechanism of action	Histamine H1 receptor antagonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488195259
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195259
IUPAC Name	2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid;hydrochloride
INCHI	InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
InChi Key	HVRLZEKDTUEKQH-NOILCQHBSA-N
Canonical SMILES	CN(C)CCC=C1C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O.Cl
Isomeric SMILES	CN(C)CC/C=C\1/C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O.Cl
WGK Germany	3
RTECS	HQ4135060
Alternate CAS	113806-05-6
PubChem CID	5282402
Molecular Weight	373.88
Reaxy-Rn	6675608

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
A2121103	Certificate of Analysis	Nov 02, 2023	O159894
B2304227	Certificate of Analysis	Dec 01, 2022	O159894
B2304229	Certificate of Analysis	Dec 01, 2022	O159894
B2304268	Certificate of Analysis	Dec 01, 2022	O159894
B2304441	Certificate of Analysis	Dec 01, 2022	O159894
B2304497	Certificate of Analysis	Dec 01, 2022	O159894
I1919124	Certificate of Analysis	Jul 20, 2022	O159894

Solubility

H2O: ≥20 mg/mL

Melt Point(°C)

248 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RTECS	HQ4135060
Reaxy-Rn	6675608
Merck Index	6840

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