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ONO-8590580 - 98%, high purity , CAS No.1802661-73-9, Allosteric modulator of GABA A receptor α5 subunit

  • Moligand™
  • ≥98%
Item Number
O412143
Grouped product items
SKUSizeAvailabilityPrice Qty
O412143-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$57.90
O412143-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
O412143-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$179.90
O412143-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90

Basic Description

SynonymsCHEMBL4581355 | CID 118278442 | 3-(cyclopropylmethyl)-6-fluoro-7-methyl-N-[5-(1-methylimidazol-4-yl)pyridin-2-yl]benzimidazol-5-amine
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsONO-8590580 is a negative allosteric modulator of GABAA α5.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of GABA A receptor α5 subunit
Product Description

Information

ONO-8590580 is a negative allosteric modulator of GABAA α5.

Associated Targets

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRG2 Tclin Gamma-aminobutyric acid receptor subunit gamma-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-(cyclopropylmethyl)-6-fluoro-7-methyl-N-[5-(1-methylimidazol-4-yl)pyridin-2-yl]benzimidazol-5-amine
INCHI InChI=1S/C21H21FN6/c1-13-20(22)16(7-18-21(13)25-12-28(18)9-14-3-4-14)26-19-6-5-15(8-23-19)17-10-27(2)11-24-17/h5-8,10-12,14H,3-4,9H2,1-2H3,(H,23,26)
InChi Key INGJMHPGMVUEKY-UHFFFAOYSA-N
Canonical SMILES CC1=C(C(=CC2=C1N=CN2CC3CC3)NC4=NC=C(C=C4)C5=CN(C=N5)C)F
Isomeric SMILES CC1=C(C(=CC2=C1N=CN2CC3CC3)NC4=NC=C(C=C4)C5=CN(C=N5)C)F
PubChem CID 118278442
MeSH Entry Terms 1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-(5-(1-methyl-1H-imidazol-4-yl)pyridin-2-yl)-1H-benzo(d)imidazol-6-amine;ONO-8590580
Molecular Weight 376.4

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
C2421612Certificate of AnalysisJan 22, 2024 O412143
C2421613Certificate of AnalysisJan 22, 2024 O412143
C2421614Certificate of AnalysisJan 22, 2024 O412143
C2421615Certificate of AnalysisJan 22, 2024 O412143
C2421616Certificate of AnalysisJan 22, 2024 O412143
C2421617Certificate of AnalysisJan 22, 2024 O412143

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