Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and ener
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In Vitro:OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50
In Vivo:Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo. MC
Biological Activity:Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and ener
