Org 48762-0 - ≥98%(HPLC), high purity , CAS No.755753-89-0

Item Number

O286758

Grouped product items
SKU	Size	Availability	Price
O286758-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$269.90
O286758-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,085.90
O286758-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,739.90

Selective p38α/β inhibitor

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Basic Description

Synonyms	Org 48762-0\|755753-89-0\|2HE2MP5Y3G\|4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine\|ORG-48762-0\|4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridyl)-2H-pyrazolo(3,4-b)pyridine\|2H-Pyrazolo(3,4-b)pyridine, 4,6-bis(4-fluorophenyl)-2-meth
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Product Description	Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.

Names and Identifiers

IUPAC Name	4,6-bis(4-fluorophenyl)-2-methyl-5-pyridin-4-ylpyrazolo[3,4-b]pyridine
INCHI	InChI=1S/C24H16F2N4/c1-30-14-20-21(15-2-6-18(25)7-3-15)22(16-10-12-27-13-11-16)23(28-24(20)29-30)17-4-8-19(26)9-5-17/h2-14H,1H3
InChi Key	VMAKTIDYMSNPOV-UHFFFAOYSA-N
Canonical SMILES	CN1C=C2C(=C(C(=NC2=N1)C3=CC=C(C=C3)F)C4=CC=NC=C4)C5=CC=C(C=C5)F
Isomeric SMILES	CN1C=C2C(=C(C(=NC2=N1)C3=CC=C(C=C3)F)C4=CC=NC=C4)C5=CC=C(C=C5)F
PubChem CID	24822135
Molecular Weight	398.41

Solubility

Solvent:DMSO, Max Conc. mg/mL: 39.84, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 19.92, Max Conc. mM: 50

Sensitivity

Light sensitive

Solution Calculators

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Basic Description