Purity≥95% (SDS-PAGE&SEC); Endotoxin Level < 0.01EU/μg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab182845-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $79.90 | |
| Ab182845-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $359.90 | |
| Ab182845-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $889.90 | |
| Ab182845-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,429.90 |
Purity≥95% (SDS-PAGE&SEC); Endotoxin Level < 0.01EU/μg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Orilanolimab (anti-FcRn (FCGRT&B2M)) - Primary antibody, specific to FCGRT & B2M, Human IgG4SP |
|---|---|
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | FCGRT & B2M |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Orilanolimab (anti-FcRn (FCGRT & B2M)) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab (anti-FcRn (FCGRT & B2M)) blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab (anti-FcRn (FCGRT & B2M)) impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab (anti-FcRn (FCGRT & B2M)) disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity.
|
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 144.6 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling FcRn (FCGRT&B2M) (red) with Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) - ELISA
Immobilized Human FcRn/FCGRT&B2M Heterodimer protein, His and Avi tag at 2.0 μg/mL can bind Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) with the EC50 of 15.67 ng/mL.
Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) - SEC
The purity of Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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