Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab177919-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $109.90 | |
| Ab177919-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $519.90 | |
| Ab177919-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,399.90 | |
| Ab177919-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,239.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | OS2966 (anti-ITGB1) - Primary antibody, specific to ITGB1, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | beta1 integrin antibody; CD_antigen=CD29 antibody; CD29 antibody; Fibronectin receptor subunit beta antibody; FNRB antibody; Glycoprotein IIa antibody; GP IIa antibody; GPIIA antibody; Integrin beta-1 antibody; Integrin subunit beta 1 antibody; integrin V |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | ITGB1 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description | OS2966 (anti-ITGB1) is a humanized monoclonal antibody directed against the human integrin receptor beta-1 subunit (CD29), with potential antineoplastic activity. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.3 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 176.1 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
OS2966 (anti-ITGB1) (Ab177919) - Flow Cytometry
Flow Cytometry analysis of U-2 OS cells labelling ITGB1 (red) with OS2966 (anti-ITGB1) (Ab177919). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
OS2966 (anti-ITGB1) (Ab177919) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling ITGB1 (red) with OS2966 (anti-ITGB1) (Ab177919). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
OS2966 (anti-ITGB1) (Ab177919) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling ITGB1 (red) with OS2966 (anti-ITGB1) (Ab177919). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
OS2966 (anti-ITGB1) (Ab177919) - SEC
The purity of OS2966 (anti-ITGB1) (Ab177919) is more than 95% verified by HPLC.
OS2966 (anti-ITGB1) (Ab177919) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ITGB1 with OS2966 (anti-ITGB1) (Ab177919) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).
OS2966 (anti-ITGB1) (Ab177919) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ITGB1 (red) with OS2966 (anti-ITGB1) (Ab177919) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0404072 | Certificate of Analysis | Apr 02, 2024 | Ab177919 |
| ZJ24F0404071 | Certificate of Analysis | Apr 02, 2024 | Ab177919 |
| ZJ24F0404070 | Certificate of Analysis | Apr 02, 2024 | Ab177919 |
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| 72. Takada, Yoko K YK and 5 more authors.. (2017) Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.. The Journal of biological chemistry, (8): [PMID:29030430] |
| 73. Takada, Yoko K; Yu, Jessica; Shimoda, Michiko and Takada, Yoshikazu.. (2019) Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:31331973] |
| 74. Alqarihi, Abdullah and 10 more authors.. (2020) GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.. mBio, (2): [PMID:32487760] |
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