OSI-027 - 95%, high purity , Serine/threonine-protein kinase mTOR inhibitor, CAS No.936890-98-1, Serine/threonine-protein kinase mTOR inhibitor

Item Number

O127920

Grouped product items
SKU	Size	Availability	Price
O127920-1mg	1mg	In stock	$28.90
O127920-5mg	5mg	In stock	$116.90
O127920-10mg	10mg	In stock	$227.90
O127920-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$626.90

Potent mTOR inhibitor

Basic Description

Synonyms	4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid \| AC-4802 \| DB12387 \| OSI 027 \| (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexane-1-carboxylic acid \| CCG-
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor.Potent, ATP-competitive mTOR kinase inhibitor. Inhibits TORC1 (IC 50 = 22 nM) and TORC2 (IC 50 = 65 nM) mTor complexes. Greater than 100-fold selective for mTOR versus PI3K-alpha, P
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Serine/threonine-protein kinase mTOR inhibitor
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name	4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid
INCHI	InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12,25H,5-8H2,1H3,(H,28,29)(H2,22,23,24)
InChi Key	JROFGZPOBKIAEW-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N
Isomeric SMILES	COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N
PubChem CID	135398516
Molecular Weight	406.45

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
I2117447	Certificate of Analysis	Jul 07, 2023	O127920
I2117448	Certificate of Analysis	Jul 07, 2023	O127920
I2117450	Certificate of Analysis	Jul 07, 2023	O127920
I2117451	Certificate of Analysis	Jul 07, 2023	O127920

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Basic Description