Otamixaban(FXV 673) is an intravenous direct factor Xa inhibitor.Otamixaban is useful for thromboembolic disorders.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Coagulation factor X inhibitor
Product Description
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.
1.Guertin KR, Gardner CJ, Klein SI, Zulli AL, Czekaj M, Gong Y, Spada AP, Cheney DL, Maignan S, Guilloteau JP et al.. (2002) Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.. Bioorg Med Chem Lett, 12 (12):(1671-4). [PMID:12039587]
2.Rensi S, Altman RB, Liu T, Lo YC, McInnes G, Derry A, Keys A. (2020) Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human Cells.. ChemRxiv, 129 (3):(589-97). [PMID:32511288]
3.Hu X, Shrimp JH, Guo H, Xu M, Chen CZ, Zhu W, Zakharov AV, Jain S, Shinn P, Simeonov A et al.. (2021) Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19.. ACS Pharmacol Transl Sci, 4 (3):(1124-1135). [PMID:34136758]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
