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Oxaliplatin - 99%, high purity , CAS No.61825-94-3

23 Citations

≥99%

CAS#: 61825-94-3
Formula: C₈H₁₄N₂O₄Pt
Molecular Weight: 397.29
MDL number: MFCD00866327
PubChem CID: 9887053
PubChem SID: 488196399

Item Number

O124003

Grouped product items
SKU	Size	Availability	Price
O124003-25mg	25mg	In stock	$21.90
O124003-100mg	100mg	In stock	$49.90
O124003-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$83.90
O124003-500mg	500mg	In stock	$132.90
O124003-1g	1g	In stock	$219.90
O124003-5g	5g	In stock	$879.90

Platinum anticancer agent. Induces DNA cross-linking.

View related series

Apoptosis Cell Cycle/DNA Damage DNA/RNA Synthesis Element classified compounds Pharmaceutical ingredients

Basic Description

Synonyms	(trans-1,2-Cyclohexanediamine)oxalatoplatinu \| [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum \| L-OHP
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin forms platinum-DNA ad
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy. Application： Oxaliplatin has been used:as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay；for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay；to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells. Product class hAPIs, Metal based hAPIs Chemical properties Chemical formula C8H14N2O4Pt Empirical formula [Pt((R,R)-dach)(ox)] Molecular weight 397.28 Metal Pt Theoretical metal content 49 Physical state powder Color white

Names and Identifiers

Pubchem Sid	488196399
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488196399
INCHI	1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
InChi Key	ZROHGHOFXNOHSO-BNTLRKBRSA-L
Canonical SMILES	C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
Isomeric SMILES	C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
WGK Germany	3
RTECS	TP2275850
PubChem CID	9887053
Molecular Weight	397.29
Reaxy-Rn	14621501

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

39 results found

Lot Number	Certificate Type	Date	Item
I2426289	Certificate of Analysis	Aug 19, 2024	O124003
I2426288	Certificate of Analysis	Aug 19, 2024	O124003
I2426287	Certificate of Analysis	Aug 19, 2024	O124003
I2426286	Certificate of Analysis	Aug 19, 2024	O124003
I2426284	Certificate of Analysis	Aug 19, 2024	O124003
E2409315	Certificate of Analysis	Apr 24, 2024	O124003
G2425020	Certificate of Analysis	Apr 24, 2024	O124003
E2409320	Certificate of Analysis	Apr 24, 2024	O124003
E2409319	Certificate of Analysis	Apr 24, 2024	O124003
E2409318	Certificate of Analysis	Apr 24, 2024	O124003
E2409317	Certificate of Analysis	Apr 24, 2024	O124003
E2409316	Certificate of Analysis	Apr 24, 2024	O124003
G2310625	Certificate of Analysis	Jun 19, 2023	O124003
G2310622	Certificate of Analysis	Jun 19, 2023	O124003
G2310615	Certificate of Analysis	Jun 19, 2023	O124003
G2310612	Certificate of Analysis	Jun 19, 2023	O124003
G2310610	Certificate of Analysis	Jun 19, 2023	O124003
G2310607	Certificate of Analysis	Jun 19, 2023	O124003
C2316153	Certificate of Analysis	Mar 08, 2023	O124003
C2316100	Certificate of Analysis	Mar 08, 2023	O124003
C2316101	Certificate of Analysis	Mar 08, 2023	O124003
C2316105	Certificate of Analysis	Mar 08, 2023	O124003
C2316106	Certificate of Analysis	Mar 08, 2023	O124003
C2316108	Certificate of Analysis	Mar 08, 2023	O124003
C2316136	Certificate of Analysis	Mar 08, 2023	O124003
C2316151	Certificate of Analysis	Mar 08, 2023	O124003
C2316175	Certificate of Analysis	Mar 08, 2023	O124003
C2316152	Certificate of Analysis	Mar 08, 2023	O124003
J2231099	Certificate of Analysis	Jul 21, 2022	O124003
H2202598	Certificate of Analysis	Jul 21, 2022	O124003
H2202585	Certificate of Analysis	Jul 21, 2022	O124003
H2202559	Certificate of Analysis	Jul 21, 2022	O124003
H2202550	Certificate of Analysis	Jul 21, 2022	O124003
H2202519	Certificate of Analysis	Jul 21, 2022	O124003
C2222546	Certificate of Analysis	Feb 18, 2022	O124003
C2222513	Certificate of Analysis	Feb 18, 2022	O124003
C2222440	Certificate of Analysis	Feb 18, 2022	O124003
C2222377	Certificate of Analysis	Feb 18, 2022	O124003
C2222376	Certificate of Analysis	Feb 18, 2022	O124003

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Chemical and Physical Properties

Solubility	DMSO：DMSO inactivates the activity of Oxaliplatin；H2O：Sonification and heating to 60℃ are recommended；DMF：Sonification is recommended；
Sensitivity	Heat Sensitive；Moisture sensitive；Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H351:Suspected of causing cancer H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P308+P313:IF exposed or concerned: Get medical advice/attention. P202:Do not handle until all safety precautions have been read and understood.
WGK Germany	3
RTECS	TP2275850
Reaxy-Rn	14621501
Merck Index	6912

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Shilin Zhou, Yuxuan Sun, Kaidi Wang, Xintao Gao, Kehong Dong, Jing Wang, Xiaochen Wu, Chuanlong Guo. (2024) Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo. FOOD AND CHEMICAL TOXICOLOGY, 184 (114427). [PMID:38160781] [10.1016/j.fct.2023.114427]
2. Chenyi Gao, Kunpeng Jia, Jun Fang, Xuan Zhu, Jianming Hu, Yi Zhang, Jinxin Jiang, Xiuyan Yu, Danting Wang, Haochen Gu, Zhigang Chen. (2023) CD95 promotes stemness of colorectal cancer cells by lncRNA MALAT1. LIFE SCIENCES, (122394). [PMID:38159593] [10.1016/j.lfs.2023.122394]
3. Shufen Zhang, Yingping Zeng, Kai Wang, Guangtao Song, Yiru Yu, Tingting Meng, Hong Yuan, Fuqiang Hu. (2023) Chitosan-based nano-micelles for potential anti-tumor immunotherapy: Synergistic effect of cGAS-STING signaling pathway activation and tumor antigen absorption. CARBOHYDRATE POLYMERS, (121346). [PMID:37739513] [10.1016/j.carbpol.2023.121346]
4. Ting Li, Wei Lu, Hui Tian, Yu Cao, Qianqian He, Xia Chen, Hailong Wang. (2023) Identification and Characterization of DNA–Oxaliplatin Adducts through α-hemolysin Nanopores. ANALYTICAL CHEMISTRY, [PMID:37417945] [10.1021/acs.analchem.3c00461]
5. Yudi Ma, Xiaohui Lai, Zhongling Wen, Ziling Zhou, Minkai Yang, Qingqing Chen, Xuan Wang, Feng Mei, Liu Yang, Tongming Yin, Shucun Sun, Guihua Lu, Jinliang Qi, Hongyan Lin, Hongwei Han, Yonghua Yang. (2023) Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. BIOORGANIC CHEMISTRY, 139 (106703). [PMID:37399615] [10.1016/j.bioorg.2023.106703]
6. Yuehong Zhang, Xuelin Huang, Wen-Jun Xin, Shilang He, Jie Deng, Xiangcai Ruan. (2023) Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice. JOURNAL OF PAIN, 24 (1020). [PMID:36641028] [10.1016/j.jpain.2023.01.002]
7. Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zhao. (2023) IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46 (1): (26-34). [PMID:36596524] [10.1248/bpb.b22-00439]
8. Yuzhu Cao, Yawen Xia, Yufei Wang, Hang Shi, Yuanyuan Wu, Yin Lu. (2023) MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells. Journal of Clinical and Translational Hepatology, 11 (3): ( 584–594). [PMID:36969904] [10.14218/JCTH.2022.00048]
9. Zhi-Bin Dong, Yu-Jia Wang, Meng-Lin Cheng, Bo-Jun Wang, Hong Lu, Hai-Li Zhu, Ling Liu, Min Xie. (2022) 2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction. PLoS One, 17 (10): (e0275428). [PMID:36315519] [10.1371/journal.pone.0275428]
10. He-Yu Yang, Ji Wu, Hong Lu, Meng-Lin Cheng, Bang-Hua Wang, Hai-Li Zhu, Ling Liu, Min Xie. (2022) Emodin suppresses oxaliplatin-induced neuropathic pain by inhibiting COX2/NF-κB mediated spinal inflammation. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 37 (1): (e23229). [PMID:36184831] [10.1002/jbt.23229]
11. Zhi-Bin Dong, Yu-Jia Wang, Wen-Jun Wan, Ji Wu, Bo-Jun Wang, Hai-Li Zhu, Min Xie, Ling Liu. (2022) Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Experimental and Therapeutic Medicine, 24 (3): (1-10). [PMID:35949346] [10.3892/etm.2022.11523]
12. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] [10.3390/ijms23126597]
13. Jing Deng, Anhong Cai, Xiao Ling, Qian Sun, Tianxin Zhu, Qingsong Li, Xueyan Li, Weizhu Chen. (2023) Comparison of UV and UV-LED activated sodium percarbonate for the degradation of O-desmethylvenlafaxine. Journal of Environmental Sciences, 126 (656). [PMID:36503791] [10.1016/j.jes.2022.05.052]
14. Qingwen Xu, Yuxi Liu, Wen Sun, Tiantian Song, Xintong Jiang, Kui Zeng, Su Zeng, Lu Chen, Lushan Yu. (2022) Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma. Cancers, 14 (10): (2551). [PMID:35626154] [10.3390/cancers14102551]
15. Yuzhu Cao, Keqin Lu, Yawen Xia, Yufei Wang, Aiyun Wang, Yang Zhao. (2022) Danshensu Attenuated Epithelial-Mesenchymal Transformation and Chemoresistance of Colon Cancer Cells Induced by Platelets. Frontiers in Bioscience-Landmark, 27 (5): (160). [PMID:35638427] [10.31083/j.fbl2705160]
16. Zhipeng Jiang, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen. (2022) Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance. Bioengineered, 13 (1): (810-823). [PMID:34974791] [10.1080/21655979.2021.2012952]
17. Yuting Shen, Liang Chen, Xin Guan, Xiaoxia Han, Xiaowan Bo, Shaoyue Li, Liping Sun, Yu Chen, Wenwen Yue, Huixiong Xu. (2021) Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation. ACS Nano, 15 (12): (20414–20429). [PMID:34881574] [10.1021/acsnano.1c08826]
18. Xiao Kuang, Dongxu Chi, Jinbo Li, Chunlin Guo, Yinxian Yang, Shuang Zhou, Cong Luo, Hongzhuo Liu, Zhonggui He, Yongjun Wang. (2021) Disulfide bond based cascade reduction-responsive Pt(IV) nanoassemblies for improved anti-tumor efficiency and biosafety. COLLOIDS AND SURFACES B-BIOINTERFACES, 203 (111766). [PMID:33866279] [10.1016/j.colsurfb.2021.111766]
19. Shan Shuhua, Lu Yang, Zhang Xiaoli, Shi Jiangying, Li Hanqing, Li Zhuoyu. (2021) Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells. MOLECULAR AND CELLULAR BIOCHEMISTRY, 476 (2): (513-523). [PMID:33011952] [10.1007/s11010-020-03906-4]
20. Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou. (2019) Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS. International Journal of Biological Sciences, 15 (8): ( 1676–1684). [PMID:31360110] [10.7150/ijbs.35265]
21. Yang Lu, Shuhua Shan, Hanqing Li, Jiangying Shi, Xiaoli Zhang, Zhuoyu Li. (2018) Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (20): (5190–5199). [PMID:29730933] [10.1021/acs.jafc.8b01659]
22. Tsai Hsiang-I, Jiang Lijuan, Zeng Xiaowei, Chen Hongbo, Li Zihuang, Cheng Wei, Zhang Jinxie, Pan Jie, Wan Dong, Gao Li, Xie Zhenhua, Huang Laiqiang, Mei Lin, Liu Gan. (2018) DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy. Frontiers in Pharmacology, 9 [PMID:29515445] [10.3389/fphar.2018.00119]
23. Gan Liu, Hongjun Gao, Yixiong Zuo, Xiaowei Zeng, Wei Tao, Hsiang-i Tsai, Lin Mei. (2017) DACHPt-Loaded Unimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers for Enhanced Therapy of Lung Cancer. ACS Applied Materials & Interfaces, 9 (1): (112–119). [PMID:27966356] [10.1021/acsami.6b11917]

References

1. Tan Z et al.. (2019) Environmental stresses induce karyotypic instability in colorectal cancer cells.. Mol Biol Cell, 30 (42-55). [PMID:30379607]
2. Vallecillo-Hernández J et al.. (2018) Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs.. Sci Rep, 8 (3593). [PMID:29483523]
3. Li D et al.. (2021) Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS.. Aging (Albany NY), 13 (3): (4242-4257). [PMID:33495407]
4. Yan S et al.. (2019) PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells.. Int J Mol Sci, 20 (21): [PMID:31671668]
5. Shilin Zhou, Yuxuan Sun, Kaidi Wang, Xintao Gao, Kehong Dong, Jing Wang, Xiaochen Wu, Chuanlong Guo. (2024) Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo. FOOD AND CHEMICAL TOXICOLOGY, 184 (114427). [PMID:38160781] [10.1016/j.fct.2023.114427]
6. Chenyi Gao, Kunpeng Jia, Jun Fang, Xuan Zhu, Jianming Hu, Yi Zhang, Jinxin Jiang, Xiuyan Yu, Danting Wang, Haochen Gu, Zhigang Chen. (2023) CD95 promotes stemness of colorectal cancer cells by lncRNA MALAT1. LIFE SCIENCES, (122394). [PMID:38159593] [10.1016/j.lfs.2023.122394]
7. Shufen Zhang, Yingping Zeng, Kai Wang, Guangtao Song, Yiru Yu, Tingting Meng, Hong Yuan, Fuqiang Hu. (2023) Chitosan-based nano-micelles for potential anti-tumor immunotherapy: Synergistic effect of cGAS-STING signaling pathway activation and tumor antigen absorption. CARBOHYDRATE POLYMERS, (121346). [PMID:37739513] [10.1016/j.carbpol.2023.121346]
8. Ting Li, Wei Lu, Hui Tian, Yu Cao, Qianqian He, Xia Chen, Hailong Wang. (2023) Identification and Characterization of DNA–Oxaliplatin Adducts through α-hemolysin Nanopores. ANALYTICAL CHEMISTRY, [PMID:37417945] [10.1021/acs.analchem.3c00461]
9. Yudi Ma, Xiaohui Lai, Zhongling Wen, Ziling Zhou, Minkai Yang, Qingqing Chen, Xuan Wang, Feng Mei, Liu Yang, Tongming Yin, Shucun Sun, Guihua Lu, Jinliang Qi, Hongyan Lin, Hongwei Han, Yonghua Yang. (2023) Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. BIOORGANIC CHEMISTRY, 139 (106703). [PMID:37399615] [10.1016/j.bioorg.2023.106703]
10. Yuehong Zhang, Xuelin Huang, Wen-Jun Xin, Shilang He, Jie Deng, Xiangcai Ruan. (2023) Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice. JOURNAL OF PAIN, 24 (1020). [PMID:36641028] [10.1016/j.jpain.2023.01.002]
11. Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zhao. (2023) IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46 (1): (26-34). [PMID:36596524] [10.1248/bpb.b22-00439]
12. Yuzhu Cao, Yawen Xia, Yufei Wang, Hang Shi, Yuanyuan Wu, Yin Lu. (2023) MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells. Journal of Clinical and Translational Hepatology, 11 (3): ( 584–594). [PMID:36969904] [10.14218/JCTH.2022.00048]
13. Zhi-Bin Dong, Yu-Jia Wang, Meng-Lin Cheng, Bo-Jun Wang, Hong Lu, Hai-Li Zhu, Ling Liu, Min Xie. (2022) 2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction. PLoS One, 17 (10): (e0275428). [PMID:36315519] [10.1371/journal.pone.0275428]
14. He-Yu Yang, Ji Wu, Hong Lu, Meng-Lin Cheng, Bang-Hua Wang, Hai-Li Zhu, Ling Liu, Min Xie. (2022) Emodin suppresses oxaliplatin-induced neuropathic pain by inhibiting COX2/NF-κB mediated spinal inflammation. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 37 (1): (e23229). [PMID:36184831] [10.1002/jbt.23229]
15. Zhi-Bin Dong, Yu-Jia Wang, Wen-Jun Wan, Ji Wu, Bo-Jun Wang, Hai-Li Zhu, Min Xie, Ling Liu. (2022) Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Experimental and Therapeutic Medicine, 24 (3): (1-10). [PMID:35949346] [10.3892/etm.2022.11523]
16. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] [10.3390/ijms23126597]
17. Jing Deng, Anhong Cai, Xiao Ling, Qian Sun, Tianxin Zhu, Qingsong Li, Xueyan Li, Weizhu Chen. (2023) Comparison of UV and UV-LED activated sodium percarbonate for the degradation of O-desmethylvenlafaxine. Journal of Environmental Sciences, 126 (656). [PMID:36503791] [10.1016/j.jes.2022.05.052]
18. Qingwen Xu, Yuxi Liu, Wen Sun, Tiantian Song, Xintong Jiang, Kui Zeng, Su Zeng, Lu Chen, Lushan Yu. (2022) Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma. Cancers, 14 (10): (2551). [PMID:35626154] [10.3390/cancers14102551]
19. Yuzhu Cao, Keqin Lu, Yawen Xia, Yufei Wang, Aiyun Wang, Yang Zhao. (2022) Danshensu Attenuated Epithelial-Mesenchymal Transformation and Chemoresistance of Colon Cancer Cells Induced by Platelets. Frontiers in Bioscience-Landmark, 27 (5): (160). [PMID:35638427] [10.31083/j.fbl2705160]
20. Zhipeng Jiang, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen. (2022) Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance. Bioengineered, 13 (1): (810-823). [PMID:34974791] [10.1080/21655979.2021.2012952]
21. Yuting Shen, Liang Chen, Xin Guan, Xiaoxia Han, Xiaowan Bo, Shaoyue Li, Liping Sun, Yu Chen, Wenwen Yue, Huixiong Xu. (2021) Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation. ACS Nano, 15 (12): (20414–20429). [PMID:34881574] [10.1021/acsnano.1c08826]
22. Xiao Kuang, Dongxu Chi, Jinbo Li, Chunlin Guo, Yinxian Yang, Shuang Zhou, Cong Luo, Hongzhuo Liu, Zhonggui He, Yongjun Wang. (2021) Disulfide bond based cascade reduction-responsive Pt(IV) nanoassemblies for improved anti-tumor efficiency and biosafety. COLLOIDS AND SURFACES B-BIOINTERFACES, 203 (111766). [PMID:33866279] [10.1016/j.colsurfb.2021.111766]
23. Shan Shuhua, Lu Yang, Zhang Xiaoli, Shi Jiangying, Li Hanqing, Li Zhuoyu. (2021) Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells. MOLECULAR AND CELLULAR BIOCHEMISTRY, 476 (2): (513-523). [PMID:33011952] [10.1007/s11010-020-03906-4]
24. Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou. (2019) Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS. International Journal of Biological Sciences, 15 (8): ( 1676–1684). [PMID:31360110] [10.7150/ijbs.35265]
25. Yang Lu, Shuhua Shan, Hanqing Li, Jiangying Shi, Xiaoli Zhang, Zhuoyu Li. (2018) Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (20): (5190–5199). [PMID:29730933] [10.1021/acs.jafc.8b01659]
26. Tsai Hsiang-I, Jiang Lijuan, Zeng Xiaowei, Chen Hongbo, Li Zihuang, Cheng Wei, Zhang Jinxie, Pan Jie, Wan Dong, Gao Li, Xie Zhenhua, Huang Laiqiang, Mei Lin, Liu Gan. (2018) DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy. Frontiers in Pharmacology, 9 [PMID:29515445] [10.3389/fphar.2018.00119]
27. Gan Liu, Hongjun Gao, Yixiong Zuo, Xiaowei Zeng, Wei Tao, Hsiang-i Tsai, Lin Mei. (2017) DACHPt-Loaded Unimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers for Enhanced Therapy of Lung Cancer. ACS Applied Materials & Interfaces, 9 (1): (112–119). [PMID:27966356] [10.1021/acsami.6b11917]

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