Oxiconazole nitrate - ≥98%, high purity , Cytochrome P450 51 inhibitor, CAS No.64211-46-7, Cytochrome P450 51 inhibitor

Item Number

O276152

• Synonyms: Oxistat | 2',4'-dichloro-2-imidazol-1-ylacetophenone (Z)-(OO-(2,4-dichlorobenzyl)oxime) mononitrate | C08075 | CHEBI:7826 | OXICONAZOLE NITRATE [MART.] | Oxistat (TN) | alpha-Benzoyltriethylammonium chloride | HMS3714A13 | OXICONAZOLE NITRATE [USP-RS] | H
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Broad-spectrum imidazole antifungal agent. Potent inducer of CYP3A4 gene expression via PXR. Active in vivo.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: Cytochrome P450 51 inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.