Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral
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Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral In vitro
Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Oxymatrine protects mice from fulminant hepatitis induced by GalN/LPS and may block hepatocyte apoptosis and subsequent necrosis through downregulating the production of serum tumor necrosis factor alpha and the expression of Fas and Fas ligand in liver tissue. ) Oxymatrine also shows anti-hepatitis B virus effect in vivo by reducing the contents of HBsAg and HBcAg in transgenic mice liver.
1.Xu Xiao, Xiaolei Hou, Wenda Shi, Chanchan Hu, Yanan Cui, Jiuli Hu, Zongfang Piao, Xiaoqin Zhu, Qingshan Li, Fan Xu. (2021) Oxymatrine inhibits proliferation and apoptosis of human breast cancer cells through the regulation of miRNA-140-5P. American Journal of Translational Research, 13 (12):( 13674–13682). [PMID:35035706][PMID:35035706]
2.Yanshi Wang, Shaojie Yang, Shanshan Zhang, Xin Wu. (2020) Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway. Cancer Management and Research, 12 ( 2057–2067). [PMID:32256113][10.2147/CMAR.S245696]
3.Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen. (2019) Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents. JOURNAL OF CHROMATOGRAPHY A, 1593 (156). [PMID:30718059][10.1016/j.chroma.2019.01.070]
4.Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943][10.1016/j.chroma.2018.07.031]
5.Juan Zhang, Zilin Chen. (2013) Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry. ANALYTICAL LETTERS, [PMID:][10.1080/00032719.2012.726684]
References
1.Xu Xiao, Xiaolei Hou, Wenda Shi, Chanchan Hu, Yanan Cui, Jiuli Hu, Zongfang Piao, Xiaoqin Zhu, Qingshan Li, Fan Xu. (2021) Oxymatrine inhibits proliferation and apoptosis of human breast cancer cells through the regulation of miRNA-140-5P. American Journal of Translational Research, 13 (12):( 13674–13682). [PMID:35035706][PMID:35035706]
2.Yanshi Wang, Shaojie Yang, Shanshan Zhang, Xin Wu. (2020) Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway. Cancer Management and Research, 12 ( 2057–2067). [PMID:32256113][10.2147/CMAR.S245696]
3.Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen. (2019) Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents. JOURNAL OF CHROMATOGRAPHY A, 1593 (156). [PMID:30718059][10.1016/j.chroma.2019.01.070]
4.Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943][10.1016/j.chroma.2018.07.031]
5.Juan Zhang, Zilin Chen. (2013) Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry. ANALYTICAL LETTERS, [PMID:][10.1080/00032719.2012.726684]
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