Oxytetracycline (Terramycin) - 10mM in DMSO, high purity , CAS No.79-57-2(DMSO)

Item Number

O407936

• Specifications & Purity: 10mM in DMSO
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Information

Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.
In vitro

In vivo

Oxytetracycline (200 mg/kg for 15 days) results a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in rat liver. Oxytetracycline also causes a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in rat liver. Oxytetracycline (200 mg/kg) combined with Naringenin (50 mg/kg b.w.t.) significantly decreases the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the rat liver. Oxytetracycline (200 mg/kg, oral for 15 days) produces hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increases plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide) in rats. Oxytetracycline significantly decreases the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).
Cell Data

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