| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P654901-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $182.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein -mediated multidrug resistance. In Vitro P-gp inhibitor 1 (12k) possesses high potency ( EC 50 =57.9±3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) resistance in K562/A02 cells (1 μM, 80 minutes). P-gp inhibitor 1 also boosts the potency of other MDR-related cytotoxic agents with different structures, increases accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity in K562/A02 MDR cells (0.1, 1, 5 μM, 1 hour). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: K562/A02 cell Concentration: 0.1, 0.5, or 2.0 μM Incubation Time: 72 hours Result: MDR reversal by 12k was not caused by a decreased protein expression but instead most likely due to direct inhibition of P-gp efflux. IC50& Target:P-glycoprotein |
| Canonical SMILES | COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC4=NC(=NC5=CC=CC=C54)C6=CC=NC=C6)OC |
|---|---|
| Molecular Weight | 517.62 |
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