| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T104623-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
| T104623-500g | 500g | In stock | $33.90 |
| Synonyms | P-TOLUENESULFONYL CHLORIDE|98-59-9|Tosyl chloride|4-Methylbenzenesulfonyl chloride|p-Tosyl chloride|4-Toluenesulfonyl chloride|4-methylbenzene-1-sulfonyl chloride|p-Toluenesulphonyl chloride|p-Tolylsulfonyl chloride|p-Toluenesulfochloride|tosylchloride|p- |
|---|---|
| Specifications & Purity | reagent grade,99% |
| Storage Temp | Argon charged |
| Shipped In | Normal |
| Grade | AR |
| Product Description | p-Toluenesulfonyl chloride is an organic sulfonyl chloride mainly used to convert hydroxyl groups into good leaving group by forming sulfonates. |
| IUPAC Name | 4-methylbenzenesulfonyl chloride |
|---|---|
| INCHI | InChI=1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3 |
| InChi Key | YYROPELSRYBVMQ-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)Cl |
| Isomeric SMILES | CC1=CC=C(C=C1)S(=O)(=O)Cl |
| WGK Germany | 1 |
| RTECS | DB8929000 |
| PubChem CID | 7397 |
| UN Number | 1759 |
| Packing Group | I |
| Molecular Weight | 190.65 |
| Beilstein | 607898 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 L2202344 | Certificate of Analysis | Sep 04, 2024 | T104623 |
| H2420179 | Certificate of Analysis | Aug 08, 2024 | T104623 |
| H2420144 | Certificate of Analysis | Aug 08, 2024 | T104623 |
| H2420143 | Certificate of Analysis | Aug 08, 2024 | T104623 |
| H2420142 | Certificate of Analysis | Aug 08, 2024 | T104623 |
| G2223115 | Certificate of Analysis | Apr 26, 2024 | T104623 |
| C2408517 | Certificate of Analysis | Mar 01, 2024 | T104623 |
| C2408522 | Certificate of Analysis | Mar 01, 2024 | T104623 |
| C2408524 | Certificate of Analysis | Mar 01, 2024 | T104623 |
| C2408525 | Certificate of Analysis | Mar 01, 2024 | T104623 |
| F2306902 | Certificate of Analysis | May 12, 2023 | T104623 |
| F2306914 | Certificate of Analysis | May 12, 2023 | T104623 |
| F2306901 | Certificate of Analysis | May 12, 2023 | T104623 |
| F2306860 | Certificate of Analysis | May 12, 2023 | T104623 |
| L2202296 | Certificate of Analysis | Oct 10, 2022 | T104623 |
| L2202307 | Certificate of Analysis | Oct 10, 2022 | T104623 |
| G2223108 | Certificate of Analysis | Jun 17, 2022 | T104623 |
| G2223109 | Certificate of Analysis | Jun 17, 2022 | T104623 |
| G2223110 | Certificate of Analysis | Jun 17, 2022 | T104623 |
| C2314531 | Certificate of Analysis | Jun 17, 2022 | T104623 |
| A2217062 | Certificate of Analysis | Jan 25, 2022 | T104623 |
| A2220146 | Certificate of Analysis | Jan 07, 2022 | T104623 |
| A2220142 | Certificate of Analysis | Jan 07, 2022 | T104623 |
| A2220141 | Certificate of Analysis | Jan 07, 2022 | T104623 |
| A2220140 | Certificate of Analysis | Jan 07, 2022 | T104623 |
| A2220135 | Certificate of Analysis | Jan 07, 2022 | T104623 |
| Solubility | Soluble in alcohol, benzene and ether. Insoluble in water. |
|---|---|
| Sensitivity | Moisture sensitive. |
| Flash Point(°F) | 262.4 °F |
| Flash Point(°C) | 128 °C |
| Boil Point(°C) | 145°C/2.0kPa |
| Melt Point(°C) | 71°C |
| Pictogram(s) | GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H315:Causes skin irritation H335:May cause respiratory irritation H314:Causes severe skin burns and eye damage H412:Harmful to aquatic life with long lasting effects H318:Causes serious eye damage H317:May cause an allergic skin reaction |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
| WGK Germany | 1 |
| RTECS | DB8929000 |
| Class | 8 |
| Merck Index | 9534 |
Starting at $582.90
Starting at $84.90
Starting at $12.90
Starting at $14.90
Starting at $32.90
Starting at $46.90
Starting at $25.90
Starting at $11.90
Starting at $19.90
Starting at $33.90
| 1. M Tomita,T Okuyama,S Watanabe,B Uno,S Kawai. (1991-05-03) High-performance liquid chromatographic determination of glyphosate and (aminomethyl)phosphonic acid in human serum after conversion into p-toluenesulphonyl derivatives.. Journal of chromatography, 566 ((1)): (239-243). [PMID:1885717] |
| 2. T S Li,Y L Li,X T Liang. (1990-06-01) Studies of the synthesis of biomarkers. VII. Synthesis of 5 alpha-(17R,20R)-14,15-secocholestane.. Steroids, 55 ((6)): (263-265). [PMID:2385850] |
| 3. D Sandrock,H C Blossey,M Steinroeder,D L Munz. (1989-01-01) Contribution of different scintigraphic techniques to the management of medullary thyroid carcinoma.. Henry Ford Hospital medical journal, 37 ((3-4)): (173-174). [PMID:2576957] |
| 4. Y Tabata,S V Lonikar,F Horii,Y Ikada. (1986-05-01) Immobilization of collagen onto polymer surfaces having hydroxyl groups.. Biomaterials, 7 ((3)): (234-238). [PMID:3719044] |
| 5. E V Dolgaia,S L Mironov,N Kh Pogorelaia. (1985-01-01) [Surface charge of mouse neuroblastoma cells and changes during growth and morphologic differentiation of the cell population].. Neirofiziologiia = Neurophysiology, 17 ((2)): (168-174). [PMID:4000300] |
| 6. J Kambayashi,T Nomura,T Fujimoto,G Kosaki. (1980-12-01) The analysis of platelet reaction, utilizing various inhibitors of platelet aggregation.. Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 43 ((6)): (1145-1154). [PMID:6800180] |
| 7. . (1982-10-01) Para-toluenesulfonyl chloride.. American Industrial Hygiene Association journal, 43 ((10)): (B53-B54). [PMID:7148678] |
| 8. I M Kung,F F Wang,Y C Chang,Y J Wang. (1995-05-01) Surface modifications of alginate/poly(L-lysine) microcapsular membranes with poly(ethylene glycol) and poly(vinyl alcohol).. Biomaterials, 16 ((8)): (649-655). [PMID:7548616] |
| 9. R J Schmidt. (1995-02-01) Tosyl chloride.. Contact dermatitis, 32 ((2)): (124-125). [PMID:7758322] |
| 10. P D Robinson,D H Hua,L A Good,H Wang,C Y Meyers. (1993-06-15) (4S,5S)-4-methyl-5-phenyl-1,3-oxazolidin-2-one.. Acta crystallographica. Section C, Crystal structure communications, 49 (( Pt 6)): (1238-1240). [PMID:8397978] |
| 11. A H Ismail,A A Ismail. (2001-08-08) Synthesis of 1,2-unsaturated pyranosylphosphonate nucleosides from 3,4,6-tri-O-acetyl-D-glycal.. Die Pharmazie, 56 ((7)): (534-535). [PMID:11487970] |
| 12. Katsunori Teranishi. (2002-03-23) Direct regioselective 2-O-(p-toluenesulfonylation) of sucrose.. Carbohydrate research, 337 ((7)): (613-619). [PMID:11909594] |
| 13. Katarzyna Dziarkowska,Jan Ake Jönsson,Piotr P Wieczorek. (2007-12-18) Single hollow fiber SLM extraction of polyamines followed by tosyl chloride derivatization and HPLC determination.. Analytica chimica acta, 606 ((2)): (184-193). [PMID:18082649] |
| 14. Ho Law,Juan M Benito,José M García Fernández,Laszlo Jicsinszky,Serge Crouzy,Jacques Defaye. (2011-05-20) Copper(II)-complex directed regioselective mono-p-toluenesulfonylation of cyclomaltoheptaose at a primary hydroxyl group position: an NMR and molecular dynamics-aided design.. The journal of physical chemistry. B, 115 ((23)): (7524-7532). [PMID:21591775] |
| 15. Rui Ding,Yong He,Xiao Wang,Jingli Xu,Yurong Chen,Man Feng,Chuanmin Qi. (2011-07-05) Treatment of alcohols with tosyl chloride does not always lead to the formation of tosylates.. Molecules (Basel, Switzerland), 16 ((7)): (5665-5673). [PMID:21725279] |
| 16. Abdelaziz Houmam,Emad M Hamed. (2011-09-15) Application of the dissociative electron transfer theory and its extension to the case of in-cage interactions in the electrochemical reduction of arene sulfonyl chlorides.. Physical chemistry chemical physics : PCCP, 14 ((1)): (113-124). [PMID:21915407] |
| 17. Ana Bárbara Dias Pereira,Talisson Machado Veríssimo,Mariana Assíria de Oliveira,Ivaldo Antônio de Araujo,Ricardo José Alves,Fernão Castro Braga. (2012-02-16) Development and validation of an HPLC-DAD method for quantification of bornesitol in extracts from Hancornia speciosa leaves after derivatization with p-toluenesulfonyl chloride.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 887-888 (133-137). [PMID:22333437] |
| 18. Haq Nawaz,Paulo Augusto R Pires,Omar A El Seoud. (2013-02-13) Kinetics and mechanism of imidazole-catalyzed acylation of cellulose in LiCl/N,N-dimethylacetamide.. Carbohydrate polymers, 92 ((2)): (997-1005). [PMID:23399120] |
| 19. Jiangxiu Niu,Aidong Wang,Zhongcheng Ke,Zubiao Zheng. (2014-05-09) Glucose transporter and folic acid receptor-mediated Pluronic P105 polymeric micelles loaded with doxorubicin for brain tumor treating.. Journal of drug targeting, 22 ((8)): (712-723). [PMID:24806516] |
| 20. André R Fajardo,Alexandre Guerry,Elizandra A Britta,Celso V Nakamura,Edvani C Muniz,Redouane Borsali,Sami Halila. (2014-05-27) Sulfated glycosaminoglycan-based block copolymer: preparation of biocompatible chondroitin sulfate-b-poly(lactic acid) micelles.. Biomacromolecules, 15 ((7)): (2691-2700). [PMID:24857763] |
| 21. Ayman M Atta,Hamad A Al-Lohedan,Abdelrahman O Ezzat. (2014-05-27) Synthesis of silver nanoparticles by green method stabilized to synthetic human stomach fluid.. Molecules (Basel, Switzerland), 19 ((5)): (6737-6753). [PMID:24858265] |
| 22. Lachlan M Blair,Elizabeth A Colby Davie,Jonathan Sperry. (2014-07-24) Total synthesis of putative montamine and a proposed structural reassignment.. Organic & biomolecular chemistry, 12 ((35)): (6878-6884). [PMID:25054306] |
| 23. Wei Li,Lili Sun,Lijun Pan,Zuopin Lan,Tao Jiang,Xiaolan Yang,Jianchun Luo,Ronghua Li,Liqing Tan,Shurong Zhang,Mingan Yu. (2014-10-14) Dendrimer-like assemblies based on organoclays as multi-host system for sustained drug delivery.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88 ((3)): (706-717). [PMID:25308929] |
| 24. Anna W Sromek,Shaohui Zhang,Vamsidhar Akurathi,Alan B Packard,Wei Li,David Alagille,Thomas J Morley,Ronald Baldwin,Gilles Tamagnan,John L Neumeyer. (2014-11-18) Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine.. Journal of labelled compounds & radiopharmaceuticals, 57 ((14)): (725-729). [PMID:25400260] |
| 25. Tsurng-Juhn Huang,Hong Chuang,Yu-Chuan Liang,Hui-Hsien Lin,Jia-Cherng Horng,Yu-Cheng Kuo,Chia-Wen Chen,Fu-Yuan Tsai,Shih-Chieh Yen,Shih-Ching Chou,Ming-Hua Hsu. (2014-12-03) Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents.. European journal of medicinal chemistry, 90 (428-435). [PMID:25461891] |
| 26. Charles H Jones,Akhila Gollakota,Mingfu Chen,Tai-Chun Chung,Anitha Ravikrishnan,Guojian Zhang,Blaine A Pfeifer. (2015-05-06) Influence of molecular weight upon mannosylated bio-synthetic hybrids for targeted antigen presenting cell gene delivery.. Biomaterials, 58 (103-111). [PMID:25941787] |
| 27. Lihua Zhi,Zhiyi Wang,Jian Liu,Weisheng Liu,Haoli Zhang,Fengjuan Chen,Baodui Wang. (2015-06-24) White emission magnetic nanoparticles as chemosensors for sensitive colorimetric and ratiometric detection, and degradation of ClO⁻ and SCN⁻ in aqueous solutions based on a logic gate approach.. Nanoscale, 7 ((27)): (11712-11719). [PMID:26102484] |
| 28. Ho-Joong Kim,Yongju Kim,Sung Cho,Myongsoo Lee. (2015-07-07) Self-Assembly of a Tripod Aromatic Rod into Stacked Planar Networks.. Chemistry (Weinheim an der Bergstrasse, Germany), 21 ((33)): (11836-11842). [PMID:26147242] |
| 29. Dries Vandamme,Samuel Eyley,Guy Van den Mooter,Koenraad Muylaert,Wim Thielemans. (2015-07-27) Highly charged cellulose-based nanocrystals as flocculants for harvesting Chlorella vulgaris.. Bioresource technology, 194 (270-275). [PMID:26210139] |
| 30. Samuel Eyley,Dries Vandamme,Sanjaya Lama,Guy Van den Mooter,Koenraad Muylaert,Wim Thielemans. (2015-08-08) CO₂ controlled flocculation of microalgae using pH responsive cellulose nanocrystals.. Nanoscale, 7 ((34)): (14413-14421). [PMID:26248574] |
| 31. Zachary C Kennedy,Carmen E Lisowski,Dumitru S Mitaru-Berceanu,James E Hutchison. (2015-10-27) Influence of Ligand Shell Composition upon Interparticle Interactions in Multifunctional Nanoparticles.. Langmuir : the ACS journal of surfaces and colloids, 31 ((46)): (12742-12752). [PMID:26497061] |
| 32. Marta Soler,Eduard Figueras,Joan Serrano-Plana,Marta González-Bártulos,Anna Massaguer,Anna Company,Ma Ángeles Martínez,Jaroslav Malina,Viktor Brabec,Lidia Feliu,Marta Planas,Xavi Ribas,Miquel Costas. (2015-10-28) Design, Preparation, and Characterization of Zn and Cu Metallopeptides Based On Tetradentate Aminopyridine Ligands Showing Enhanced DNA Cleavage Activity.. Inorganic chemistry, 54 ((22)): (10542-10558). [PMID:26503063] |
| 33. Dae-Yoon Kim,Sang-A Lee,Daseal Jung,Jahyeon Koo,Jin Soo Kim,Yeon-Tae Yu,Cheul-Ro Lee,Kwang-Un Jeong. (2017-08-02) Topochemical polymerization of dumbbell-shaped diacetylene monomers: relationship between chemical structure, molecular packing structure, and gelation property.. Soft matter, 13 ((34)): (5759-5766). [PMID:28761944] |
| 34. Shuang Bai,Meili Hou,Xiaoxiao Shi,Jiucun Chen,Xiaoqian Ma,Yong-E Gao,Yajun Wang,Peng Xue,Yuejun Kang,Zhigang Xu. (2018-05-19) Reduction-active polymeric prodrug micelles based on α-cyclodextrin polyrotaxanes for triggered drug release and enhanced cancer therapy.. Carbohydrate polymers, 193 (153-162). [PMID:29773367] |
| 35. Rimesh Augustine,Dae-Kyoung Kim,Nagendra Kalva,Kuen Hee Eom,Jae Ho Kim,Il Kim. (2020-06-11) Multi-stimuli-responsive nanomicelles fabricated using synthetic polymer polylysine conjugates for tumor microenvironment dependent drug delivery.. Journal of materials chemistry. B, 8 ((26)): (5745-5755). [PMID:32519736] |
| 36. H Egg,H Leibetseder,A Patzak,L Steinkellner. (1987-03-01) [Degradation reactions of oral antidiabetics. 2. Reaction of arylsulfonylureas with 4-toluenesulfonyl chloride].. Archiv der Pharmazie, 320 ((3)): (253-257). [PMID:3579526] |
| 37. Hassan Y Aboul-Enein,Mohamed O I Refaie,Hayam El-Gazzar,Magda Abd El-Aziz. (2003-08-15) Chemical modification of milk xanthine oxidase with different modifiers.. Preparative biochemistry & biotechnology, 33 ((3)): (173-187). [PMID:12916809] |
| 38. Rince Wong,Sarah J Dolman. (2007-04-21) Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts.. The Journal of organic chemistry, 72 ((10)): (3969-3971). [PMID:17444687] |
| 39. Silje B Torsetnes,Maren S Levernæs,Marianne N Broughton,Elisabeth Paus,Trine G Halvorsen,Léon Reubsaet. (2014-06-20) Multiplexing determination of small cell lung cancer biomarkers and their isovariants in serum by immunocapture LC-MS/MS.. Analytical chemistry, 86 ((14)): (6983-6992). [PMID:24945626] |
| 40. Haibo Mu,Hu Bai,Feifei Sun,Yinyin Liu,Chunbo Lu,Yuanhao Qiu,Peng Chen,Yu Yang,Lili Kong,Jinyou Duan. (2019-09-08) Pathogen-targeting glycovesicles as a therapy for salmonellosis.. Nature communications, 10 ((1)): (4039-4039). [PMID:31492864] |
| 41. Kuldeep Kumar Bansal,Ezgi Özliseli,Gaurav Kumar Saraogi,Jessica M Rosenholm. (2020-08-05) Assessment of Intracellular Delivery Potential of Novel Sustainable Poly(δ-decalactone)-Based Micelles.. Pharmaceutics, 12 ((8)): [PMID:32748816] |
| 42. Maxim V Khrolenko,Piotr P Wieczorek. (2005-10-20) Determination of glyphosate and its metabolite aminomethylphosphonic acid in fruit juices using supported-liquid membrane preconcentration method with high-performance liquid chromatography and UV detection after derivatization with p-toluenesulphonyl chloride.. Journal of chromatography. A, 1093 ((1-2)): (111-117). [PMID:16233876] |
