PAD2-IN-1 hydrochloride - 99%, high purity , CAS No.P658847

  • ≥99%
Item Number
P658847
Grouped product items
SKUSizeAvailabilityPrice Qty
P658847-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$350.90
P658847-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$950.90

Basic Description

Specifications & Purity99%
Storage TempStore at 2-8°C,Protected from light,Desiccated
Shipped InWet ice
Product Description

PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

Appearance:Solid

IC50& Target:Protein Arginine Deiminase 2 (PAD2)

In Vitro:In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells. PAD2-IN-1 (compound 32a; 1-25 μM) hydrochlori

Biological Activity:AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

Names and Identifiers

Canonical SMILES O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl
Molecular Weight 517

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

SolubilityDMSO : 100 mg/mL (193.42 mM; Need ultrasonic)

Related Documents

Solution Calculators