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Paeoniflorin - ≥98%(HPLC), high purity , CAS No.23180-57-6

  • ≥98%(HPLC)
Item Number
P101691
Grouped product items
SKUSizeAvailabilityPrice Qty
P101691-100mg
100mg
In stock
$79.90
P101691-500mg
500mg
In stock
$239.90
P101691-5g
5g
In stock
$1,679.90
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Chemical Biology monosaccharide

Basic Description

SynonymsPaeoniflorin|23180-57-6|Peoniflorin|Paeonia moutan|NSC 178886|UNII-21AIQ4EV64|21AIQ4EV64|CCRIS 6494|EINECS 245-476-2|PAEONIFLORIN (USP-RS)|PAEONIFLORIN [USP-RS]|NSC-178886|((2S,2aR,2a1S,3aR,4R,5aR)-4-Hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy
Specifications & Purity≥98%(HPLC)
Storage TempRoom temperature
Shipped InNormal

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488189795
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189795
IUPAC Name [(1R,2S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate
INCHI InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1
InChi Key YKRGDOXKVOZESV-WRJNSLSBSA-N
Canonical SMILES C[C@@]12C[C@@]3(O)O[C@@H](O1)[C@]5(COC(=O)c4ccccc4)[C@H]3C[C@]25O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O
Isomeric SMILES C[C@]12C[C@@]3([C@@H]4C[C@]1([C@@]4([C@H](O2)O3)COC(=O)C5=CC=CC=C5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O
WGK Germany 3
PubChem CID 442534
Molecular Weight 480.46

Certificates

Certificate of Analysis(COA)

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7 results found

Lot NumberCertificate TypeDateItem
D23261057Certificate of AnalysisMay 06, 2023 P101691
D2326892Certificate of AnalysisMay 06, 2023 P101691
D2326898Certificate of AnalysisMay 06, 2023 P101691
D2326903Certificate of AnalysisMay 06, 2023 P101691
D2326916Certificate of AnalysisMay 06, 2023 P101691
D2326969Certificate of AnalysisMay 06, 2023 P101691
C23241008Certificate of AnalysisJan 15, 2022 P101691

Chemical and Physical Properties

SensitivityHeat Sensitive
Specific Rotation[α]-14 ° (C=1, MeOH)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

References

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2. Youn-Hwan Hwang,Taesoo Kim,Won-Kyung Cho,Doorye Jang,Jung-Ho Ha,Jin Yeul Ma.  (2012-05-01)  Food- and gender-dependent pharmacokinetics of paeoniflorin after oral administration with Samul-tang in rats..  Journal of ethnopharmacology,  142  ((1)): (161-167).  [PMID:22543167]
3. Rong Wang,Xiaoguo Peng,Liming Wang,Beibei Tan,Jiangyun Liu,Yulin Feng,Shilin Yang.  (2012-06-08)  Preparative purification of peoniflorin and albiflorin from peony rhizome using macroporous resin and medium-pressure liquid chromatography..  Journal of separation science,  35  ((15)): (1985-1992).  [PMID:22674837]
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5. Dandan Liu,Peipei Li,Shanshan Song,Yunjie Liu,Qingtong Wang,Yan Chang,Yujing Wu,Jingyu Chen,Wendi Zhao,Lingling Zhang,Wei Wei.  (2012-07-05)  Pro-apoptotic effect of epigallo-catechin-3-gallate on B lymphocytes through regulating BAFF/PI3K/Akt/mTOR signaling in rats with collagen-induced arthritis..  European journal of pharmacology,  690  ((1-3)): (214-225).  [PMID:22760071]
6. Shiguang Sun,Mingqi Qiao,Huiyun Zhang.  (2012-07-12)  [Treatment of premenstrual syndrome with Chinese medicine formula, baixiangdan capsule: implications for neuron viability and GABA(A) receptor modulation in rat cortex]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  36  ((11)): (1508-1511).  [PMID:22779188]
7. Osamu Morinaga,Zhaohua Lu,Lidong Lin,Takuhiro Uto,Suphattra Sangmalee,Waraporn Putalun,Hiroyuki Tanaka,Yukihiro Shoyama.  (2012-07-12)  Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody..  Phytochemical analysis : PCA,  24  ((2)): (124-128).  [PMID:22782934]
8. Di Wang,Fang Yuan,Liwen Wang,Wei Wei.  (2012-07-28)  Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by rhIL-1β..  International immunopharmacology,  14  ((2)): (172-178).  [PMID:22835428]
9. Jie Wu,Hong Shen,Jun Xu,Ling-Ying Zhu,Xiao-Bin Jia,Song-Lin Li.  (2012-07-28)  Detection of sulfur-fumigated Paeoniae Alba Radix in complex preparations by high performance liquid chromatography tandem mass spectrometry..  Molecules (Basel, Switzerland),  17  ((8)): (8938-8954).  [PMID:22836213]
10. Hitomi Hino,Hisaaki Takahashi,Yuka Suzuki,Junya Tanaka,Eiichi Ishii,Mitsumasa Fukuda.  (2012-08-24)  Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children..  PloS one,  7  ((8)): (e42920-e42920).  [PMID:22916181]
11. Yan Chen,Jinyan Wang,Ran Xin,Xiaobin Tan.  (2012-09-25)  [Impact of saikosaponin on absorption and transport of paeoniflorin in Caco-2 cell model]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((12)): (1850-1854).  [PMID:22997838]
12. Huan Xu,Jie Song,Xinghua Gao,Zhao Xu,Xianxiang Xu,Yufeng Xia,Yue Dai.  (2012-10-12)  Paeoniflorin attenuates lipopolysaccharide-induced permeability of endothelial cells: involvements of F-actin expression and phosphorylations of PI3K/Akt and PKC..  Inflammation,  36  ((1)): (216-225).  [PMID:23053726]
13. Ruo-Bing Guo,Guo-Feng Wang,An-Peng Zhao,Jun Gu,Xiu-Lan Sun,Gang Hu.  (2012-11-21)  Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses..  PloS one,  7  ((11)): (e49701-e49701).  [PMID:23166749]
14. Jian-Zhe Li,Shu-Yi Yu,Jian-Hua Wu,Qing-Rui Shao,Xiao-Min Dong.  (2012-12-06)  Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase..  Canadian journal of physiology and pharmacology,  90  ((12)): (1569-1575).  [PMID:23210435]
15. Chun Wang,Jun Yuan,Zhao-Yi Yang,Xin-Xin Nie,Li-Hua Song,Wei Wei.  (2013-01-26)  Pharmacokinetics of paeoniflorin microemulsion after repeated dosing in rats with adjuvant arthritis..  Die Pharmazie,  67  ((12)): (997-1001).  [PMID:23346762]
16. Jing Yu,Xiaoyun Zhu,Xin Qi,Juanjuan Che,Bangwei Cao.  (2013-02-14)  Paeoniflorin protects human EA.hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway..  Toxicology letters,  218  ((3)): (224-234).  [PMID:23403272]
17. Yingrong Chen,Chenglu Gao,Yueming Ma,Furong Qiu.  (2013-02-23)  Pharmacokinetic study of multiple active constituents after oral gavage of Guizhi decoction in rats using a LC-MS/MS method..  European journal of drug metabolism and pharmacokinetics,  38  ((4)): (283-293).  [PMID:23430690]
18. Rui Hou,Lan Wang,Mao-Bo Du,Ri-Xin Liang,Shu-Zhi Liu,Yan-Li Wang,Jian-Yong Zhang.  (2013-03-13)  [Pharmacokinetic study on three main ingredients of refined coronary cataplasm]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((23)): (3641-3646).  [PMID:23477156]
19. Zeng-Yao Hu,Lan Xu,Rong Yan,Yan Huang,Gang Liu,Wen-Xia Zhou,Yong-Xiang Zhang.  (2013-05-15)  [Advance in studies on effect of paeoniflorin on nervous system]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((3)): (297-301).  [PMID:23667997]
20. Bohyoung Lee,Jin Bae Weon,Bo-Ra Yun,Jiwoo Lee,Min Rye Eom,Choong Je Ma.  (2013-06-07)  Simultaneous determination of 11 major components in Palmul-tang by HPLC-DAD and LC-MS-MS..  Journal of chromatographic science,  52  ((6)): (482-492).  [PMID:23741048]
21. Jian-Jun Zhang,Yin-Feng Huang,Li-Li Wang,Wei Li,Jing-Xia Wang,Chun Wang,Sheng-Sheng Qu.  (2014-01-16)  [Comparative study on effects of blood enriching on mouse model of blood deficiency syndrome induced by compound method of bleeding, starved feeding and exhausting of Paeoniae Radix Alba and Paeoniae Radix Rubra, paeoniflorin and albiflorin]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((19)): (3358-3362).  [PMID:24422408]
22. Genichiro Sumi,Katsuhiko Yasuda,Chiharu Kanamori,Megumi Kajimoto,Akemi Nishigaki,Tomoko Tsuzuki,Hisayuu Cho,Hidetaka Okada,Hideharu Kanzaki.  (2014-04-18)  Two-step inhibitory effect of kanzo on oxytocin-induced and prostaglandin F2α-induced uterine myometrial contractions..  Journal of natural medicines,  68  ((3)): (550-560).  [PMID:24740432]
23. Yuefeng Li,Pingan Wu,Yanmei Ning,Xingke Yan,Tiantian Zhu,Chongbing Ma,Anguo Liu.  (2014-05-03)  Sedative and hypnotic effect of freeze-dried paeoniflorin and sini san freeze-dried powder in pentobarbital sodium-induced mice..  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan,  34  ((2)): (184-187).  [PMID:24783931]
24. Wen Xu,Mingqing Huang,Huang Li,Xianwen Chen,Yuqin Zhang,Jie Liu,Wei Xu,Kedan Chu,Lidian Chen.  (2015-02-25)  Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  986-987  (69-84).  [PMID:25710597]
25. Mee-Young Lee,Chang-Sebo Seo,Ji-Young Kim,Hyeun-Kyoo Shin.  (2015-07-17)  Evaluation of a water extract of So-Cheong-Ryong-Tang for acute toxicity and genotoxicity using in vitro and in vivo tests..  BMC complementary and alternative medicine,  15  (235-235).  [PMID:26178777]
26. Nina Yin,Qinghua Gao,Wenting Tao,Jiaojiao Chen,Jing Bi,Fengmin Ding,Zhigang Wang.  (2020-02-23)  Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1..  Journal of leukocyte biology,  108  ((1)): (229-241).  [PMID:32083340]
27. Minwoo Hwang,Jeong Nam Kim,Jong Rok Lee,Sang Chan Kim,Byung Joo Kim.  (2020-04-03)  Effects of Chaihu-Shugan-San on Small Intestinal Interstitial Cells of Cajal in Mice..  Biological & pharmaceutical bulletin,  43  ((4)): (707-715).  [PMID:32238713]
28. Wei Zhang,Sheng-Ming Dai.  (2012-06-19)  Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis..  International immunopharmacology,  14  ((1)): (27-31).  [PMID:22705050]
29. Yan Chen,Lei Zhou,Ran Xin,Jinyan Wang,Xiaobin Jia.  (2012-10-02)  [Multi-channel analysis and comparison on absorption difference between paeoniflorin and Paeonia lactiflora extracts]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((13)): (2012-2016).  [PMID:23019889]
30. Shanshan Hu,Wuyi Sun,Wei Wei,Di Wang,Juan Jin,Jingjing Wu,Jingyu Chen,Huaxun Wu,Qingtong Wang.  (2012-10-17)  Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosis..  Anti-cancer drugs,  24  ((2)): (140-149).  [PMID:23069790]
31. Shuying Wang,Ling Liu.  (2012-12-14)  [Protective effect of paeoniflorin on Abeta25-35 -induced PC12 cell injury]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((16)): (2448-2451).  [PMID:23234147]
32. Xiaorong Chen,Cheng Liu,Yunfei Lu,Zongguo Yang,Zhen Lv,Qingnian Xu,Qi Pan,Lingqing Lu.  (2012-12-15)  Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats..  BMC complementary and alternative medicine,  12  (254-254).  [PMID:23237422]
33. Hsiang-Ru Lin.  (2013-01-04)  Paeoniflorin acts as a liver X receptor agonist..  Journal of Asian natural products research,  15  ((1)): (35-45).  [PMID:23281636]
34. Feng-Mei Qiu,Xiao-Ming Zhong,Qing-Qiu Mao,Zhen Huang.  (2013-03-14)  Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress..  Neuroscience letters,  541  (209-213).  [PMID:23481217]
35. Shung-Te Kao,Shulhn-Der Wang,Chih-Che Lin,Li-Jen Lin.  (2018-09-02)  Jin Gui Shen Qi Wan, a traditional Chinese medicine, alleviated allergic airway hypersensitivity and inflammatory cell infiltration in a chronic asthma mouse model..  Journal of ethnopharmacology,  227  (181-190).  [PMID:30172058]
36. Naglaa Fathy Abd El-Aal,Eman Hassan Abdelbary.  (2018-11-12)  Paeoniflorin in experimental BALB/c mansoniasis: A novel anti-angiogenic therapy..  Experimental parasitology,  197  (85-92).  [PMID:30414842]
37. Tao Wang,Ling Xu,Lei Gao,Lin Zhao,Xin-Hong Liu,Yan-Yan Chang,Yun-Lin Liu.  (2020-04-05)  Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats..  Metabolic brain disease,  35  ((6)): (959-970).  [PMID:32246322]

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