Pafuramidine - ≥98%, high purity , CAS No.186953-56-0

Item Number

P125387

Grouped product items
SKU	Size	Availability	Price
P125387-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
P125387-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$229.90
P125387-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$364.90
P125387-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$729.90
P125387-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,169.90

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Basic Description

Synonyms	Pafuramidine\|186953-56-0\|Pafuramidine [INN]\|N'-methoxy-4-[5-[4-[(Z)-N'-methoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide\|H1VG379J2X\|DB-289\|DB289 cpd\|UNII-H1VG379J2X\|CHEMBL319669\|SCHEMBL12348156\|AKOS030526680\|CS-1470\|DB06532\|HY-14932\|MS-25808\|F
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Description: IC50 Value: 4.5 nM(In vitro inhibitory activity against Trypanosoma brucei rhodesiense) [4] DB289 (pafuramidine maleate; 2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) is a prodrug of DB75 (furamidine dihydro
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Pafuramidine (DB289) is an orally active proagent of Furamidine. Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.

Names and Identifiers

IUPAC Name	N'-methoxy-4-[5-[4-[(Z)-N'-methoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide
INCHI	InChI=1S/C20H20N4O3/c1-25-23-19(21)15-7-3-13(4-8-15)17-11-12-18(27-17)14-5-9-16(10-6-14)20(22)24-26-2/h3-12H,1-2H3,(H2,21,23)(H2,22,24)
InChi Key	UKOQVLAXCBRRGH-UHFFFAOYSA-N
Canonical SMILES	CON=C(C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)C(=NOC)N)N
Isomeric SMILES	CO/N=C(\N)/C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)/C(=N/OC)/N
PubChem CID	5480200
Molecular Weight	364.40

PubChem CID

CAS Registry No.

ChEMBL Ligand

DrugBank Ligand

Antibiotic DB

References

1. Midgley I, Fitzpatrick K, Taylor LM, Houchen TL, Henderson SJ, Wright SJ, Cybulski ZR, John BA, McBurney A, Boykin DW et al.. (2007) Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).. Drug Metab Dispos, 35 (6): (955-67). [PMID:17360833]

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Basic Description