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Pamrevlumab (anti-CTGF) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCN2/CTGF, >95%, high purity, Human IgG1, INHIBITOR of Connective tissue growth factor inhibitor

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Application: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
  • Species reactivity(Reacts with): Human,Mouse,Rabbit,Rat
  • Isotype: Human IgG1
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab169278
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab169278-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
Ab169278-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$177.90
Ab169278-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$477.90
Ab169278-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$777.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NamePamrevlumab (anti-CTGF) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCN2/CTGF, >95%, high purity, Human IgG1
SynonymsCCN 2 antibody; CCN family member 2 antibody; CCN2 antibody; Connective tissue growth factor antibody; Ctgf antibody; CTGF_HUMAN antibody; Hcs 24 antibody; Hcs24 antibody; Hypertrophic chondrocyte specific protein 24 antibody; Hypertrophic chondrocyte-spe
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityCCN2/CTGF
ApplicationELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeINHIBITOR
Mechanism of actionINHIBITOR of Connective tissue growth factor inhibitor
Product Description

Pamrevlumab, a recombinant human antibody that binds to connective tissue growth factor (CTGF) has emerged as a potential therapy for idiopathic pulmonary fibrosis (IPF).
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE27.2 kDa (Light Chain) & 52.6 kDa (Heavy Chain), under reducing conditions; 177.4 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
SourceCHO supernatant
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS946415-13-0

Images

Pamrevlumab (anti-CTGF) (Ab169278) - SEC
The purity of Pamrevlumab (anti-CTGF) (Ab169278) is more than 95% verified by HPLC.

Pamrevlumab (anti-CTGF) (Ab169278) - ELISA
Immobilized CTGF-His at 2 μg/mL can bind Pamrevlumab (anti-CTGF) (Ab169278) with the EC₅₀ of 6.73 ng/mL.

Associated Targets

CTGF Tbio Connective tissue growth factor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0901135Certificate of AnalysisSep 24, 2023 Ab169278
ZJ23F0901134Certificate of AnalysisSep 24, 2023 Ab169278

Related Documents

References

1. Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R et al..  (2006)  Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis..  Cancer Res,  66  (11): (5816-27).  [PMID:16740721]
2. Wang Q, Usinger W, Nichols B, Gray J, Xu L, Seeley TW, Brenner M, Guo G, Zhang W, Oliver N et al..  (2011)  Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease..  Fibrogenesis Tissue Repair,  (1): (4).  [PMID:21284856]
3. Chuang PY, Menon MC, He JC.  (2013)  Molecular targets for treatment of kidney fibrosis..  J Mol Med,  91  (5): (549-59).  [PMID:23179685]
4. Lipson KE, Wong C, Teng Y, Spong S.  (2012)  CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis..  Fibrogenesis Tissue Repair,  (Suppl 1): (S24).  [PMID:23259531]
5. Neesse A, Frese KK, Bapiro TE, Nakagawa T, Sternlicht MD, Seeley TW, Pilarsky C, Jodrell DI, Spong SM, Tuveson DA.  (2013)  CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer..  Proc Natl Acad Sci USA,  110  (30): (12325-30).  [PMID:23836645]
6. Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E.  (2013)  Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy..  Hum Mol Genet,  22  (24): (4938-51).  [PMID:23904456]
7. Igarashi, A A, Bradham, D M DM, Okochi, H H and Grotendorst, G R GR..  (1992)  Connective tissue growth factor..  The Journal of dermatology,      [PMID:1293144]
8. Bradham, D M DM, Igarashi, A A, Potter, R L RL and Grotendorst, G R GR..  (1991)  Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10..  The Journal of cell biology,      [PMID:1654338]
9. Oemar, B S BS and 9 more authors..  (1997)  Human connective tissue growth factor is expressed in advanced atherosclerotic lesions..  Circulation,    (18):   [PMID:9054739]
10. Nakanishi, T T and 7 more authors..  (2000)  Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture..  Endocrinology,      [PMID:10614647]
11. Ball, D K DK, Rachfal, A W AW, Kemper, S A SA and Brigstock, D R DR..  (2003)  The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion..  The Journal of endocrinology,      [PMID:12553878]

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