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Pamrevlumab (anti-CTGF) (Ab169278) - SEC
The purity of Pamrevlumab (anti-CTGF) (Ab169278) is more than 95% verified by HPLC.
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
SKU | Size | Availability | Price | Qty |
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Ab169278-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
Ab169278-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $177.90 | |
Ab169278-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $477.90 | |
Ab169278-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $777.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Product Name | Pamrevlumab (anti-CTGF) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCN2/CTGF, >95%, high purity, Human IgG1 |
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Synonyms | CCN 2 antibody; CCN family member 2 antibody; CCN2 antibody; Connective tissue growth factor antibody; Ctgf antibody; CTGF_HUMAN antibody; Hcs 24 antibody; Hcs24 antibody; Hypertrophic chondrocyte specific protein 24 antibody; Hypertrophic chondrocyte-spe |
Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
Specificity | CCN2/CTGF |
Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
Conjugation | Unconjugated |
Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
Action Type | INHIBITOR |
Mechanism of action | INHIBITOR of Connective tissue growth factor inhibitor |
Product Description | Pamrevlumab, a recombinant human antibody that binds to connective tissue growth factor (CTGF) has emerged as a potential therapy for idiopathic pulmonary fibrosis (IPF). |
Antibody Type | Primary antibody |
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Clonality | Recombinant |
Isotype | Human IgG1 |
Light Chain Type | kappa |
SDS-PAGE | 27.2 kDa (Light Chain) & 52.6 kDa (Heavy Chain), under reducing conditions; 177.4 kDa, under non-reducing conditions. |
Purification Method | Protein A purified |
Purity | >95% |
Source | CHO supernatant |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
CAS | 946415-13-0 |
Pamrevlumab (anti-CTGF) (Ab169278) - SEC
The purity of Pamrevlumab (anti-CTGF) (Ab169278) is more than 95% verified by HPLC.
Pamrevlumab (anti-CTGF) (Ab169278) - ELISA
Immobilized CTGF-His at 2 μg/mL can bind Pamrevlumab (anti-CTGF) (Ab169278) with the EC₅₀ of 6.73 ng/mL.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IMGT/mAb-DB | 554 |
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Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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ZJ23F0901135 | Certificate of Analysis | Sep 24, 2023 | Ab169278 |
ZJ23F0901134 | Certificate of Analysis | Sep 24, 2023 | Ab169278 |
1. Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R et al.. (2006) Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis.. Cancer Res, 66 (11): (5816-27). [PMID:16740721] |
2. Wang Q, Usinger W, Nichols B, Gray J, Xu L, Seeley TW, Brenner M, Guo G, Zhang W, Oliver N et al.. (2011) Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease.. Fibrogenesis Tissue Repair, 4 (1): (4). [PMID:21284856] |
3. Chuang PY, Menon MC, He JC. (2013) Molecular targets for treatment of kidney fibrosis.. J Mol Med, 91 (5): (549-59). [PMID:23179685] |
4. Lipson KE, Wong C, Teng Y, Spong S. (2012) CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis.. Fibrogenesis Tissue Repair, 5 (Suppl 1): (S24). [PMID:23259531] |
5. Neesse A, Frese KK, Bapiro TE, Nakagawa T, Sternlicht MD, Seeley TW, Pilarsky C, Jodrell DI, Spong SM, Tuveson DA. (2013) CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer.. Proc Natl Acad Sci USA, 110 (30): (12325-30). [PMID:23836645] |
6. Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. (2013) Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy.. Hum Mol Genet, 22 (24): (4938-51). [PMID:23904456] |
7. Igarashi, A A, Bradham, D M DM, Okochi, H H and Grotendorst, G R GR.. (1992) Connective tissue growth factor.. The Journal of dermatology, [PMID:1293144] |
8. Bradham, D M DM, Igarashi, A A, Potter, R L RL and Grotendorst, G R GR.. (1991) Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.. The Journal of cell biology, [PMID:1654338] |
9. Oemar, B S BS and 9 more authors.. (1997) Human connective tissue growth factor is expressed in advanced atherosclerotic lesions.. Circulation, (18): [PMID:9054739] |
10. Nakanishi, T T and 7 more authors.. (2000) Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.. Endocrinology, [PMID:10614647] |
11. Ball, D K DK, Rachfal, A W AW, Kemper, S A SA and Brigstock, D R DR.. (2003) The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.. The Journal of endocrinology, [PMID:12553878] |