Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
P655692-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $528.90 |
Specifications & Purity | 10mM in DMSO |
---|---|
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity ( IC 50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent In Vivo Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g Dosage: 0.3, 1, 3, 30 mg/kg Administration: Subcutanous injections Result: Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex. IC50& Target:IC50: 6 nM (sigma receptor) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Canonical SMILES | COC1=CC=C(C=C1)N2CC(OC2=O)CN3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O |
---|---|
Molecular Weight | 426.46 |
Enter Lot Number to search for COA: