| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P129711-1g | 1g | In stock | $152.90 | |
| P129711-5g | 5g | In stock | $381.90 |
5-HT uptake inhibitor
| Synonyms | Paroxetine hydrochloride hemihydrate|110429-35-1|Paxil|X2ELS050D8|Seroxat|Aropax|Paroxetine.HCl.hemihydrate|Paxil (TN)|(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-1-ium;chloride|(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluo |
|---|---|
| Specifications & Purity | ≥98% (HPLC) |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6). |
| ALogP | 3.5 |
|---|
| IUPAC Name | (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrate;dihydrochloride |
|---|---|
| INCHI | InChI=1S/2C19H20FNO3.2ClH.H2O/c2*20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;;/h2*1-6,9,14,17,21H,7-8,10-12H2;2*1H;1H2/t2*14-,17-;;;/m00.../s1 |
| InChi Key | MQZOATSIFWSKKT-OASXIEIISA-N |
| Canonical SMILES | C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl |
| Isomeric SMILES | C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl |
| WGK Germany | 3 |
| RTECS | TM4569320 |
| Alternate CAS | 78246-49-8 |
| PubChem CID | 5282487 |
| Molecular Weight | 374.83 |
| Reaxy-Rn | 7471375 |
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F1510065 | Certificate of Analysis | Jan 19, 2023 | P129711 |
| F2204606 | Certificate of Analysis | Jun 09, 2022 | P129711 |
| F2204608 | Certificate of Analysis | Jun 09, 2022 | P129711 |
| Solubility | Soluble in DMSO (25 mg/ml), chloroform, and methanol. Insoluble in water |
|---|---|
| Specific Rotation[α] | -90°C |
| Melt Point(°C) | 137-139°C |
| Pictogram(s) | GHS08, GHS09, GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | TM4569320 |
| Reaxy-Rn | 7471375 |
| Merck Index | 7043 |
| 1. Mongeau R et al.. (2010) 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment.. J Neurochem, 115 (2): (438-49). [PMID:20796171] |
| 2. Toulme E et al.. (2010) P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.. J Gen Physiol, 135 (4): (333-53). [PMID:20231374] |
