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Pascolizumab (anti-IL-4) - Primary antibody, specific to IL4, >95%, high purity, Human IgG1, INHIBITOR of Interleukin-4 inhibitor

Azide Free
Carrier Free
ExactAb™
Low Endotoxin
Recombinant
Validated
≥95%(SDS-PAGE&SEC)
Lot by Lot

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human,Mouse
Isotype: Human IgG1

Application:

Animal Model
ELISA
Flow Cytometry
Functional Assay

Item Number

Ab175625

Grouped product items
SKU	Size	Availability	Price
Ab175625-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab175625-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$329.90
Ab175625-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$869.90
Ab175625-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,379.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Accession#:P05112 Gene ID:3565 IL4

Basic Description

Product Name	Pascolizumab (anti-IL-4) - Primary antibody, specific to IL4, >95%, high purity, Human IgG1
Synonyms	B cell growth factor 1 antibody; B cell IgG differentiation factor antibody; B Cell Stimulatory Factor 1 antibody; B-cell stimulatory factor 1 antibody; BCGF 1 antibody; BCGF1 antibody; Binetrakin antibody; BSF-1 antibody; BSF1 antibody; IGG1 induction fa
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	IL4
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	INHIBITOR of Interleukin-4 inhibitor
Product Description	Pascolizumab (anti-IL-4) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab (anti-IL-4) has the potential for the research of asthma.

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 176.4 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95%
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	331243-22-2

IMGT/mAb-DB

Wikipedia

Pascolizumab

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0202892	Certificate of Analysis	Mar 01, 2024	Ab175625
ZJ24F0202891	Certificate of Analysis	Mar 01, 2024	Ab175625
ZJ24F0202890	Certificate of Analysis	Mar 01, 2024	Ab175625

References

1. Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM. (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.. Clin Exp Immunol, 130 (1): (93-100). [PMID:12296858]
2. Walter, M R MR and 9 more authors.. (1992) Crystal structure of recombinant human interleukin-4.. The Journal of biological chemistry, (5): [PMID:1400355]
3. Wlodawer, A A, Wlodaver, A A, Pavlovsky, A A and Gustchina, A A.. (1992) Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.. FEBS letters, (31): [PMID:1511746]
4. Powers, R R and 5 more authors.. (1992) 1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-dimensional double- and triple-resonance heteronuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:1567880]
5. Garrett, D S DS and 5 more authors.. (1992) Determination of the secondary structure and folding topology of human interleukin-4 using three-dimensional heteronuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:1567881]
6. Smith, L J LJ and 6 more authors.. (1992) Human interleukin 4. The solution structure of a four-helix bundle protein.. Journal of molecular biology, (20): [PMID:1569578]
7. Redfield, C C and 6 more authors.. (1991) Secondary structure and topology of human interleukin 4 in solution.. Biochemistry, (19): [PMID:1932028]
8. Curtis, B M BM and 8 more authors.. (1991) Experimental and theoretical studies of the three-dimensional structure of human interleukin-4.. Proteins, [PMID:1946344]
9. Carr, C C, Aykent, S S, Kimack, N M NM and Levine, A D AD.. (1991) Disulfide assignments in recombinant mouse and human interleukin 4.. Biochemistry, (12): [PMID:1993171]
10. Arai, N N and 9 more authors.. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:2535858]
11. Yokota, T T and 8 more authors.. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3016727]
12. Eder, A A, Krafft-Czepa, H H and Krammer, P H PH.. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.. Nucleic acids research, (25): [PMID:3257560]
13. Smith, L J LJ and 8 more authors.. (1994) Comparison of four independently determined structures of human recombinant interleukin-4.. Nature structural biology, [PMID:7664036]
14. Klein, S C SC, Golverdingen, J G JG, Bouwens, A G AG, Tilanus, M G MG and de Weger, R A RA.. (1995) An alternatively spliced interleukin 4 form in lymphoid cells.. Immunogenetics, [PMID:7806280]
15. Müller, T T, Dieckmann, T T, Sebald, W W and Oschkinat, H H.. (1994) Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.. Journal of molecular biology, (8): [PMID:8151703]
16. Hage, T T, Sebald, W W and Reinemer, P P.. (1999) Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.. Cell, (16): [PMID:10219247]
17. Hülsmeyer, M M, Scheufler, C C and Dreyer, M K MK.. (2001) Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.. Acta crystallographica. Section D, Biological crystallography, [PMID:11526337]
18. Zee, Robert Y L RY and 6 more authors.. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.. Human molecular genetics, (15): [PMID:14681304]
19. LaPorte, Sherry L SL and 7 more authors.. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.. Cell, (25): [PMID:18243101]
20. Powers, R R and 5 more authors.. (1992) Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.. Science (New York, N.Y.), (19): [PMID:1609277]
21. Malabarba, M G MG and 7 more authors.. (1995) Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.. The Journal of biological chemistry, (21): [PMID:7721895]

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Pascolizumab (anti-IL-4) - Primary antibody, specific to IL4, >95%, high purity, Human IgG1, INHIBITOR of Interleukin-4 inhibitor

Basic Description

Product Properties

Images

Associated Targets

IL4 Tbio Interleukin-4 0 Activities

Database links