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Home Applications Targets Kinases Pazopanib HCl (GW786034 HCl) - ≥98%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.635702-64-6, Vascular endothelial growth factor receptor inhibitor
Pazopanib HCl (GW786034 HCl) - ≥98%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.635702-64-6, Vascular endothelial growth factor receptor inhibitor
Basic Description Synonyms GW786034 HCl | 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride | pazopanib HCl | Pazopanib HCl (GW786034 HCl) | 5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylben Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel, multitargeted inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, FGFR, c-Kit and c-fms with IC50 values of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Vascular endothelial growth factor receptor inhibitor Note 25mg卖完停产，不再备货 Product Description Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
Names and Identifiers IUPAC Name 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride INCHI InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H InChi Key MQHIQUBXFFAOMK-UHFFFAOYSA-N Canonical SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl Isomeric SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl PubChem CID 11525740 Molecular Weight 473.98
Chemical and Physical Properties Solubility Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (30 mg/ml at 25 °C). Sensitivity Air Sensitive,Hygroscopic,Heat Sensitive
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 Signal Danger Hazard Statements H351: Suspected of causing cancer
H411: Toxic to aquatic life with long lasting effects
H400: Very toxic to aquatic life
H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
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