Inhibitor of platelet derived growth factor receptor alpha
Product Description
PDGFR Tyrosine Kinase Inhibitor II is a cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. PDGFR Tyrosine Kinase Inhibitor II is reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. PDGFR Tyrosine Kinase Inhibitor II is suspected to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
1.Mahboobi S, Teller S, Pongratz H, Hufsky H, Sellmer A, Botzki A, Uecker A, Beckers T, Baasner S, Schächtele C et al.. (2002) Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.. J Med Chem, 45 (5):(1002-18). [PMID:11855980]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
