PDGFR Tyrosine Kinase Inhibitor III - ≥98%, high purity , CAS No.205254-94-0, Inhibitor of platelet derived growth factor receptor beta

Item Number

P338497

• Synonyms: PDGFR Tyrosine Kinase Inhibitor III|PDGF Receptor Tyrosine Kinase Inhibitor III|205254-94-0|4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide|CHEMBL102346|1-Piperazinecarboxamide, 4-(6,7-dimethoxy-4-quinazolinyl)-N-(4-phenoxyphe
• Specifications & Purity: Moligand™, ≥98%
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of platelet derived growth factor receptor beta

Product Description

PDGFR Tyrosine Kinase Inhibitor III is a cell-permeable, potent, selective, and ATP-competitive inhibitor of the PDGFR family of tyrosine kinases (IC|50|= 50 nM for PDGFR-α, 80 nM for PDGFR-β, 50 nM for c-Kit, and 230 nM for Flt-3/Flk-2). PDGFR Tyrosine Kinase Inhibitor III inhibits the activities of other kinases only at much higher concentrations (IC50 > 30μM for EGFR, FGFR, Src, PKA, and PKC). Reported to block PDGF-BB-induced proliferation of porcine aorta smooth muscle cells (IC|50|= 250 nM).