| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P638964-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $542.90 |
PDPH
| Storage Temp | Store at 2-8°C,Desiccated |
|---|---|
| Shipped In | Wet ice |
| Product Description | Product introduction： PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates). Features of PDPH : • Reactive groups:pyridyldisulfide andhydrazide • Reactive toward: sulfhydryl groups and carbonyl (aldehyde) groups • Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable) • Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates • Usesodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups • Use withEDC to conjugate primary amine of hydrazide group to carboxyl groups Product References: Crosslinker Application Guide -- search for recent literature references for this product • Reactive Moiety:Hydrazide,Pyridyldisulfide • Crosslinker Type:Heterobifunctional • Form:Powder: • Spacer:Short(<10 Å),Cleavable:By Thiols • Labeling Method:Chemical Labeling • Spacer Arm Length:9.2 Å |
| Reactivity | Carbohydrate-Sulfhydryl |
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| Molecular Weight | 229.32 |
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Enter Lot Number to search for COA:
| Solubility | DMF,DMSO |
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| 1. Atkinson SF, Bettinger T, Seymour LW, Behr JP, Ward CM. () Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells.. J Biol Chem, [PMID:11359781] |
| 2. Govindan SV, Goldenberg DM, Griffiths GL, Leung SO, Losman MJ, Hansen HJ. () Site-specific modifications of light chain glycosylated antilymphoma (LL2) and anti-carcinoembryonic antigen (hImmu-14-N) antibody divalent f1agments.. Cancer Res, [PMID:7493334] |
| 3. Bäckman C, Rose GM, Hoffer BJ, Henry MA, Bartus RT, Friden P, Granholm AC. () Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy.. J Neurosci, [PMID:8757256] |
