| Product Description | Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC 50 s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casei Appearance:Solid IC50& Target:IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease) In Vitro:Pepstatin (Pepstatin A) (7 μM; 48 h) affects the intracellular processing of HIV-specific gag protein. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:Pepstatin (Pepstatin A) has a very low toxicity, with LD 50 s of 1090mg/kg, 875mg/kg, 820mg/kg and 450mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000mg/kg for all species by oral route. Pepstatin (0.5-50mg/kg, p.o.) suppresses Biological Activity:Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC 50 s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casei |
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