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Perindoprilat , CAS No.95153-31-4, Inhibitor of Angiotensin-converting enzyme

  • Moligand™
Item Number
P334937
Grouped product items
SKUSizeAvailabilityPrice Qty
P334937-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$285.90
P334937-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$522.90
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an angiotensin-converting enzyme (ACE) inhibitor

View related series
Angiotensin-converting enzyme Inhibitor

Basic Description

SynonymsPerindoprilat|95153-31-4|Perindoprilate|Perindoprilato|Perindoprilatum|S-9780|perondropilat|Perindopril diacid form|Perindoprilatum [Latin]|UNII-2UV6ZNQ92K|2UV6ZNQ92K|S 9780|BRN 4207072|CHEBI:132041|DTXSID90869249|(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl
Specifications & PurityMoligand™
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Angiotensin-converting enzyme
Product Description

Perindoprilat is an active metabolite of Perindopril , an ACE (angiotensin converting enzyme) inhibitor, which modulates the activity of low density lipoprotein receptor-related protein (LRP). LRP is a multifunctional endocytic receptor, which functions in the turnover of proteases and the degradation of extracellular matrix proteins. It is known that Perindoprilat inhibits the conversion of angiotensin I into angiotensin II, which lowers arteriolar pressure and increases venous capacity.

Product Properties

pKapKa: 2.27 (Predicted), pKa: 8.13 (Predicted)

Associated Targets

ABCB1 Tchem Multidrug resistance protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
INCHI InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1
InChi Key ODAIHABQVKJNIY-PEDHHIEDSA-N
Canonical SMILES CCCC(C(=O)O)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
Isomeric SMILES CCC[C@@H](C(=O)O)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O
RTECS ND6007250
PubChem CID 72022
Molecular Weight 340.41

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in ethanol, methanol, and water.
Refractive Indexn20D1.54 (Predicted)
Boil Point(°C)~568.1° C at 760 mmHg (Predicted)
Melt Point(°C)136-140° C

Safety and Hazards(GHS)

RTECS ND6007250

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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