PF-00356231 hydrochloride - 99%, high purity , CAS No.820223-77-6

Item Number

P649077

Grouped product items
SKU	Size	Availability	Price
P649077-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$135.90
P649077-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
P649077-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$640.90
P649077-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,280.90

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Basic Description

Specifications & Purity	99%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Product Description	PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 ( IC 50 =1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13 , MMP-8 , MMP-9 , MMP-3 with IC 50 s of 0.00065, 1.7, 0.98, 0.39 μM, respectively In Vitro PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC 50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MMP-12 1.4 μM (IC 50 ) MMP13 0.65 nM (IC 50 ) MMP-3 0.39 μM (IC 50 ) MMP-8 1.7 μM (IC 50 ) MMP-9 0.98 μM (IC 50 )

Names and Identifiers

IUPAC Name	(3R)-3-phenyl-3-[[4-(4-pyridin-4-ylphenyl)thiophene-2-carbonyl]amino]propanoic acid;hydrochloride
INCHI	InChI=1S/C25H20N2O3S.ClH/c28-24(29)15-22(20-4-2-1-3-5-20)27-25(30)23-14-21(16-31-23)18-8-6-17(7-9-18)19-10-12-26-13-11-19;/h1-14,16,22H,15H2,(H,27,30)(H,28,29);1H/t22-;/m1./s1
InChi Key	AEKSZORLKGTXFF-VZYDHVRKSA-N
Canonical SMILES	C1=CC=C(C=C1)C(CC(=O)O)NC(=O)C2=CC(=CS2)C3=CC=C(C=C3)C4=CC=NC=C4.Cl
PubChem CID	132951358
Molecular Weight	464.96

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Basic Description