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PF-00489791 , Phosphodiesterase 5A inhibitor, CAS No.853003-48-2, Phosphodiesterase 5A inhibitor

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PF-00489791 , Phosphodiesterase 5A inhibitor, CAS No.853003-48-2, Phosphodiesterase 5A inhibitor

Moligand™

CAS#: 853003-48-2
Formula: C₂₀H₂₈N₈O₄S
Molecular Weight: 476.6
PubChem CID: 11465695

Item Number

P612719

Grouped product items
SKU	Size	Availability	Price	Qty
P612719-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
P612719-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,600.90

View related series

phosphodiesterase 5A Inhibitor

Basic Description

Synonyms	PF-00489791\|853003-48-2\|PF-489791\|PF-489,791\|UK-489,791\|1H-Pyrazolo(4,3-d)pyrimidine-3-carboxamide, 1-(2-ethoxyethyl)-5-(ethylmethylamino)-7-((4-methyl-2-pyridinyl)amino)-N-(methylsulfonyl)\|2S27T3DSZ3\|UNII-2S27T3DSZ3\|1-(2-Ethoxyethyl)-5-(ethyl(methyl)amin
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Phosphodiesterase 5A inhibitor

Product Properties

ALogP	1.6

Associated Targets

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase 1 Activities

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(2-ethoxyethyl)-5-(ethyl-methylamino)-7-[(4-methylpyridin-2-yl)amino]-N-methylsulfonylpyrazolo[5,4-e]pyrimidine-3-carboxamide
INCHI	InChI=1S/C20H28N8O4S/c1-6-27(4)20-23-15-16(19(29)26-33(5,30)31)25-28(10-11-32-7-2)17(15)18(24-20)22-14-12-13(3)8-9-21-14/h8-9,12H,6-7,10-11H2,1-5H3,(H,26,29)(H,21,22,23,24)
InChi Key	ZUHZNKJIJDAJFD-UHFFFAOYSA-N
Canonical SMILES	CCOCCn1nc(c2c1c(Nc1nccc(c1)C)nc(n2)N(CC)C)C(=O)NS(=O)(=O)C
Isomeric SMILES	CCN(C)C1=NC2=C(C(=N1)NC3=NC=CC(=C3)C)N(N=C2C(=O)NS(=O)(=O)C)CCOCC
PubChem CID	11465695
Molecular Weight	476.6

Database links

PubChem CID	11465695
CAS Registry No.	853003-48-2

Certificates

Certificate of Analysis(COA)

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References

1. Wolk R, Smith WB, Neutel JM, Rubino J, Xuan D, Mancuso J, Gilbert J, Pressler ML. (2009) Blood pressure lowering effects of a new long-acting inhibitor of phosphodiesterase 5 in patients with mild to moderate hypertension.. Hypertension, 53 (6): (1091-7). [PMID:19398651]

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