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PF-01247324 , CAS No.875051-72-2, Channel blocker of Na v1.8

Moligand™

CAS#: 875051-72-2
Formula: C₁₃H₁₀Cl₃N₃O
Molecular Weight: 330.6
PubChem CID: 11659955

Item Number

P612721

Grouped product items
SKU	Size	Availability	Price	Qty
P612721-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
P612721-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

Nav1.8 Channel blocker

Basic Description

Synonyms	875051-72-2\|PF-01247324\|6-amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide\|6-amino-N-methyl-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide\|2-Pyridinecarboxamide, 6-amino-N-methyl-5-(2,3,5-trichlorophenyl)-\|CHEMBL3589894\|PF01247324\|PF 01247324\|GTPL852
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of Na v1.8

Associated Targets

SCN2A Tclin Sodium channel protein type 2 subunit alpha 0 Activities

Discover Target: SCN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN5A Tclin Sodium channel protein type 5 subunit alpha 1 Activities

Discover Target: SCN5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN10A Tclin Sodium channel protein type 10 subunit alpha 3 Activities

Discover Target: SCN10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN3A Tclin Sodium channel protein type 3 subunit alpha 0 Activities

Discover Target: SCN3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN9A Tclin Sodium channel protein type 9 subunit alpha 0 Activities

Discover Target: SCN9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN1A Tclin Sodium channel protein type 1 subunit alpha 0 Activities

Discover Target: SCN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-amino-N-methyl-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide
INCHI	InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20)
InChi Key	HPIUHDCRVYDAEJ-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=NC(=C(C=C1)C2=C(C(=CC(=C2)Cl)Cl)Cl)N
Isomeric SMILES	CNC(=O)C1=NC(=C(C=C1)C2=C(C(=CC(=C2)Cl)Cl)Cl)N
PubChem CID	11659955
Molecular Weight	330.6

PubChem CID

11659955

CAS Registry No.

875051-72-2

References

1. Payne CE, Brown AR, Theile JW, Loucif AJ, Alexandrou AJ, Fuller MD, Mahoney JH, Antonio BM, Gerlach AC, Printzenhoff DM et al.. (2015) A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.. Br J Pharmacol, 172 (10): (2654-70). [PMID:25625641]

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