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PF-03654746 - ≥98%, high purity , Histamine H3 receptor antagonist, CAS No.935840-31-6, Histamine H3 receptor antagonist
Basic Description Synonyms PF-03654746|935840-31-6|PF 03654746|G3QE979K1X|CHEMBL2151197|(1R,3R)-N-Ethyl-3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)cyclobutane-1-carboxamide|N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide|N-ethyl-3-fl Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Histamine H3 receptor antagonist Product Description PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)
Names and Identifiers IUPAC Name N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide INCHI InChI=1S/C18H24F2N2O/c1-2-21-17(23)14-10-18(20,11-14)15-6-5-13(16(19)9-15)12-22-7-3-4-8-22/h5-6,9,14H,2-4,7-8,10-12H2,1H3,(H,21,23) InChi Key SXMBKHYDZOCBMT-UHFFFAOYSA-N Canonical SMILES CCNC(=O)C1CC(C1)(C2=CC(=C(C=C2)CN3CCCC3)F)F Isomeric SMILES CCNC(=O)C1CC(C1)(C2=CC(=C(C=C2)CN3CCCC3)F)F Alternate CAS 935840-31-6 PubChem CID 16119086 MeSH Entry Terms N-ethyl-3-fluoro-3-(3-fluoro-4-(pyrrolidinylmethyl)phenyl)cyclobutanecarboxamide;PF 03654746;PF-03654746;PF03654746 Molecular Weight 322.39
References 1. Wager TT, Pettersen BA, Schmidt AW, Spracklin DK, Mente S, Butler TW, Howard H, Lettiere DJ, Rubitski DM, Wong DF et al. . (2011) Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).. J Med Chem, 54 (21): (7602-20). [PMID:21928839 ] 2. Stokes JR, Romero Jr FA, Allan RJ, Phillips PG, Hackman F, Misfeldt J, Casale TB. (2012) The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms.. J Allergy Clin Immunol, 129 (2): (409-12, 412.e1-2). [PMID:22196768 ]
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