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PF-04191834 , Arachidonate 5-lipoxygenase inhibitor, CAS No.1029317-21-2, Arachidonate 5-lipoxygenase inhibitor
Basic Description
| Synonyms | PF-4191834|1029317-21-2|PF-04191834|UNII-YX55DXP4T1|YX55DXP4T1|4-(3-(4-(1-methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide|PF 04191834|2H-Pyran-4-carboxamide, tetrahydro-4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)-|4- |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Arachidonate 5-lipoxygenase inhibitor |
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Names and Identifiers
| IUPAC Name | 4-[3-[4-(2-methylpyrazol-3-yl)phenyl]sulfanylphenyl]oxane-4-carboxamide |
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| INCHI | InChI=1S/C22H23N3O2S/c1-25-20(9-12-24-25)16-5-7-18(8-6-16)28-19-4-2-3-17(15-19)22(21(23)26)10-13-27-14-11-22/h2-9,12,15H,10-11,13-14H2,1H3,(H2,23,26) |
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| InChi Key | DVNQWYLVSNPCJZ-UHFFFAOYSA-N |
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| Canonical SMILES | CN1C(=CC=N1)C2=CC=C(C=C2)SC3=CC=CC(=C3)C4(CCOCC4)C(=O)N |
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| Isomeric SMILES | CN1C(=CC=N1)C2=CC=C(C=C2)SC3=CC=CC(=C3)C4(CCOCC4)C(=O)N |
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| PubChem CID | 24986635 |
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| Molecular Weight | 393.5 |
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Safety and Hazards(GHS)
| RIDADR | NONHforallmodesoftransport |
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References
| 1. Masferrer JL, Zweifel BS, Hardy M, Anderson GD, Dufield D, Cortes-Burgos L, Pufahl RA, Graneto M. (2010) Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain.. J Pharmacol Exp Ther, 334 (1): (294-301). [PMID:20378715] |
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