PF 04449913 maleate - ≥98%(HPLC), high purity , Smoothened homolog antagonist, CAS No.2030410-25-2, Smoothened homolog antagonist

Item Number

P287483

Grouped product items
SKU	Size	Availability	Price	Qty
P287483-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$81.90
P287483-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$321.90

Potent Smo antagonist

Basic Description

Synonyms	GLASDEGIB MALEATE [JAN] \| 2030410-25-2 (maleate) \| Glasdegib maleate \| 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt \| 2030410-25-2 \| D11107 \| DTXSID301027747 \| 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylp
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent Smo antagonist (IC50= 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	ANTAGONIST
Mechanism of action	Smoothened homolog antagonist

Names and Identifiers

IUPAC Name	1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea;(Z)-but-2-enedioic acid
INCHI	InChI=1S/C21H22N6O.C4H4O4/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20;5-3(6)1-2-4(7)8/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28);1-2H,(H,5,6)(H,7,8)/b;2-1-/t16-,19-;/m1./s1
InChi Key	VJCVKWFBWAVYOC-UIXXXISESA-N
Canonical SMILES	CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N.C(=CC(=O)O)C(=O)O
Isomeric SMILES	CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N.C(=C\C(=O)O)\C(=O)O
PubChem CID	122640033
Molecular Weight	490.51

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Basic Description