PF-04634817 , C-C chemokine receptor type 5 antagonist, CAS No.1228111-63-4, C-C chemokine receptor type 5 antagonist

Item Number

P612727

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SKU	Size	Availability	Price	Qty
P612727-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
P612727-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	PF-04634817\|1228111-63-4\|51M3FB9B9E\|[(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[(1S,4S)-5-[6-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone\|1,5-Anhydro-2,3-dideoxy-4-O-methyl-3-(((1R,3S)-3-(1-me
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	C-C chemokine receptor type 5 antagonist

Names and Identifiers

IUPAC Name	[(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[(1S,4S)-5-[6-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
INCHI	InChI=1S/C25H36F3N5O3/c1-15(2)24(6-4-16(10-24)31-19-5-7-36-13-20(19)35-3)23(34)33-12-17-8-18(33)11-32(17)22-9-21(25(26,27)28)29-14-30-22/h9,14-20,31H,4-8,10-13H2,1-3H3/t16-,17+,18+,19+,20-,24+/m1/s1
InChi Key	MCRWZBYTLVCCJJ-DKALBXGISA-N
Canonical SMILES	CC(C)C1(CCC(C1)NC2CCOCC2OC)C(=O)N3CC4CC3CN4C5=NC=NC(=C5)C(F)(F)F
Isomeric SMILES	CC(C)[C@@]1(CC[C@H](C1)N[C@H]2CCOC[C@H]2OC)C(=O)N3C[C@@H]4C[C@H]3CN4C5=NC=NC(=C5)C(F)(F)F
Alternate CAS	1228111-63-4
PubChem CID	46198579
MeSH Entry Terms	1,5-Anhydro-2,3-dideoxy-3-(((1R,3S)-3-isopropyl-3-(((1S,4S)-5-(6-(trifluoromethyl)-4-pyrimidinyl)-2,5-diazabicyclo(2.2.1)hept-2-yl)carbonyl)cyclopentyl)amino)-4-O-methyl-D-erythro-pentitol;PF-04634817
Molecular Weight	511.6

PubChem CID

CAS Registry No.

GPCRdb Ligand

References

1. Romero-Aroca P, Baget-Bernaldiz M, Pareja-Rios A, Lopez-Galvez M, Navarro-Gil R, Verges R. (2016) Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory.. J Diabetes Res, 2016 (3): (2156273). [PMID:27761468]
2. Gale JD, Berger B, Gilbert S, Popa S, Sultan MB, Schachar RA, Girgenti D, Perros-Huguet C. (2018) A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema.. Invest Ophthalmol Vis Sci, 59 (6): (2659-2669). [PMID:29847672]

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Basic Description